Abstract
Perhaps the best-studied and most widely recognized inducer of melanogenesis (tanning) in human skin is solar ultraviolet (UV) radiation. Although the regulation of melanogenesis is incompletely understood, evidence suggests that UV-induced DNA is at least one of the initial signals that stimulates melanogenesis in response to UV irradiation1. First, the action spectrum for the tanning response in human skin is essentially the same as that for the induction of the major DNA photoproducts2,3. Second, enhancing DNA repair by treatment of UV-irradiated melanocyte cells with the prokaryotic DNA repair enzyme T4 endonuclease V approximately doubles the melanin content of these cells over a 4 day period as compared with irradiated cells treated with either heat- inactivated enzyme or diluent alone4.
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References
Gilchrest, B.A., and Eller, M. S. DNA photodamage stimulates melanogenesis and other photoprotective responses. J Investig Dermatol Symp Proc 1999; 4: 35–40.
Parrish, J.A., Jaenicke, K.F., Anderson, R.R. Erythema and melanogenesis action spectra of normal human skin. Photochem Photobiol 1982; 36: 187–91.
Freeman, S.E., Hacham, H., Gange, RW., et al. Wavelength dependence of pyrimidine dimer formation in DNA of human skin irradiated in situ with ultraviolet light. Proc Natl AcadSci USA 1989; 86; 5605–9.
Gilchrest, B.A., Zhai, S., Eller, M.S., et al. Treatment of human melanocytes and S91 melanoma cells with the DNA repair enzyme T4 endonuclease V enhances melanogenesis after ultraviolet irradiation. J Invest Dermatol 1993; 101: 666–72.
Eller, M.S., Ostrom, K., Gilchrest, B.A. DNA damage enhances melanogenesis. Proc Natl AcadSci USA, 1996; 93:1087–1092.
Hadley, M.E., Levine, N. Pigmentation and Pigmentary Disorders, ed. Levine, N. CRC, Boca Raton, FL 1993:95–114.
Fuller, B.B., Lunsford, J.B., Iman D.S., et al. Alpha-melanocyte-stimulating hormone regulation of tyrosinase in Cloudman S-91 mouse melanoma cell cultures. J Biol Chem. 1987; 262: 4024–4033.
Donatien, P.D., Hunt, G., Pieron, C. The expression of functional MSH receptors on cultured human melanocytes. Arch Dermatol Res. 1992; 284:424–426.
Bolognia, J., Murray, M., Pawelek, J. UVB-induced melanogenesis may be mediated through the MSH-receptor system. J Invest Dermatol 1989; 92: 651–656.
Eller, M.S., Yaar, M., Gilchrest, B.A. DNA damage and melanogenesis. Nature 1994; 372: 413–414.
Hadshiew, I.M., Eller, M.S., Gasparro, F.P., Gilchrest, B.A. Stimulation of melanogenesis by DNA oligonucleotides: effect of size, sequence and 5’ phosphorylation. J Dermatol Sci 2001; 25: 127–138.
Pedeux,R, Al-Irani, N., Mateau, C., et al. Thymidine dinucleotides induce S phase cell cycle arrest in addition to increased melanogenesis in human melanocytes. J Invest Dermatol 1998; 111:472–477.
Eller, M.S., Maeda, T., Magnoni, C., et al. Enhancement of DNA repair in human skin cells by thymidine dinucleotides: Evidence for a p53-mediated mammalian SOS response. Proc Natl Acad Sci USA 1997; 94:12627–12632.
Maeda, T, Eller, MS, Hedayati, M, et al. Enhanced repair of benzo(a)pyrene-induced DNA damage in human cells treated with thymidine dinucleotides. Mutat Res 1999; 433:137–145.
Cruz, P.D Jr, Leverkus, M., Dougherty, I., et al. Thymidine dinucleotides inhibit contact hypersensitivity and activate the gene for tumor necrosis factor a. J Invest Dermatol 2000; 114:253–258.
Khlgatian, M., Asawanonda, P., Eller, M.S. et al.Tyrosinase expression is regulated by p53. J Invest Dermatol 1999; 112: 548.
Khlgatian, M.K., Hadshiew, I.M., Asawanonda, P. et al.Tyrosianse gene expression is regulated by p53. J Invest Dermatol, (In press).
Eller, M.S. Hadshiew I.M., Puri N. et al. The single-stranded telomeric DNA induces DNA damage responses. J Invest Dermatol 2000; 114:756.
Campisi, J. Replicative senescence: an old lives tale? Cell 1996; 84:497–500.
Greider, C.W. Telomere length regulation. Annu Rev Biochem 1996; 65:337–365.
Feng, J., Funk, W.D., Wang, S.S., et al. The RNA component of human telomerase. Science 1995; 269:1236–1241.
Harrington, L., McPhail, T., Mar, V., et al. A mammalian telomerase-associated protein. Science 1997; 275:973–977.
Nakamura, T.M., Morin, G.B., Chapman, K.B., et al. Telomerase catalytic subunit homologs from fission yeast and human. Science 1997; 277:955–957.
de Lange, T. Telomeres and senescence: ending the debate. Science 1998; 279:334–335.
Dimri, G.P., Itahana, K., Acosta, M., Campisi, J. Regulation of a senescence checkpoint response by the E2F1 transcription factor and pl4ARF tumor suppressor. Mol Cell Biol 2000; 20:273–285.
Atadja, P., Wong, H., Garkavtsev, I. Increased activity of p53 in senescing fibroblasts. Proc Natl Acad Sci USA 1995; 92: 8348–8352.
Campisi, J., Dimri, G.P., Hara, E. Control of replicative senescence, In E. Scneider and J Rowe (ed.) Handbook of the biology of aging, 4th ed. Academic Press, New York, NY. 1996; 121–149.
DiLeonardo, A., Linke, S.P., Clarkin, K., Wahl, G.M. DNA damage triggers a prolonged p53-dependent GI arrest and long-term induction of Cipl in normal human fibroblasts. Genes Dev. 1994; 8: 2540–2551.
Griffith, J.D. Comeau, L., Rosenfeld, S., et al. Mammalian telomeres end in a large duplex loop. Cell 1999; 97:503–514.
van Steensel, B., Smogorewska, A., de Lange, T. TRF2 protects telomeres from end-to-end fusions. Cell 1998; 92:401–413.
Karlseder J., Broccoli D., Dai Y., et al. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 1999; 283:1321–1325.
Blackburn, E. Telomere states and cell fates. Nature 2000; 408: 53–56.
Baumann, P., Cech, T.R. Potl the putative telomere end-binding protein in fission yeast and humans. Science 2001; 292: 1171–1175.
Haddad, M.M., Xu, W., Schwahn, D.J., Liao, F., et al. Activation of a cAMP pathway and induction of melanogenesis correlate with association of pl6(INK4) and p27(KIPl) to CDKs, loss of E2F-binding activity, and premature senescence of human melanocytes. Exp Cell Res 1999; 253: 561–72.
Chen, Q.M., Bartholomew, J.C., Campisi, J., et al. Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control Gl arrest but not cell replication. Biochem J 1998; 332: 43–50.
Serrano, M., Lin, A.W., McCurrach, M.E., et al. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and pl6INK4a. Cell 1997; 88: 593–602.
Zhu, J., Woods, D., McMahon, M., Bishop, J.M. Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev. 1998; 12: 2997–3007.
Stein, G.H., Drullinger, L.F., Soulard, A. and Dulic, V. Differential roles for cyclin-dependent kinase inhibitors p21 and pi 6 in the mechanisms of senescence and differentiation in human fibroblasts. Mol. Cell. Biol. 1999; 19: 2109–2117.
Dimri, G.P., Lee, X., Basile, G., et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995; 92: 9363–9367.
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Previously designated pTpT; in the oligonucleotide designation used here, “p” refers to a 5’ phosphate group; all other bases are joined by phosphodiester linkages.
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Eller, M.S., Hadshiew, I.M., Gilchrest, B.A. (2002). The Role of DNA Damage in Melanogenesis: Potential Role for Telomeres. In: Holick, M.F. (eds) Biologic Effects of Light 2001. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0937-0_8
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