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Ultraviolet a Radiation-Induced Signal Transduction in Human Keratinocytes

  • Jean Krutmann
  • Susanne Grether-Beck

Abstract

The ultraviolet (UV) radiation solar spectrum that reaches the earth consists of short wavelength UVC (< 280 nm), intermediate wavelength UVB (280–320 nm) and long wavelength UVA (320–400 nm) radiation. Under physiological conditions, human cells are exclusively exposed to UVB and UVA radiation, because ozone in the stratosphere completely absorbs wavelengths < 290 nm. The amount of UVA radiation reaching the earth’s surface is approximately 20 times greater than that of UVB radiation, and solar UVA radiation contributes to photoageing and photocarcinogenesis of human skin and is responsible for triggering the most frequent photodermatoses, that is polymorphous light eruption (Urbach, 1992).

Keywords

Singlet Oxygen Human Keratinocytes Rose Bengal Localize Scleroderma Urticaria Pigmentosa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Jean Krutmann
    • 1
  • Susanne Grether-Beck
    • 1
  1. 1.Clinical and Experimental Photodermatology, Department of DermatologyHeinrich-Heine-UniversityDüsseldorfGermany

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