Oxygen Consumption Measurements of the Myocardium in the Human Being

  • Christian J. F. Holubarsch
Part of the Basic Science for the Cardiologist book series (BASC, volume 10)


One might argue that the best way to study myocardial energetics is to measure the myocardial oxygen consumption of patients and healthy subjects in vivo — possibly before and after an acute or chronic pharmacological intervention. Although this idea is intriguing, there is a number of limitations for such a procedure. (1) Such a kind of procedure is invasive and time-consuming, and therefore some ethical considerations come into play (see below). (2) In the whole organism, any inotropic or vasodilating pharmacological intervention is necessarily followed by reflex neuroendocrine mechanisms which make interpretations of altered myocardial oxygen consumption invalid or at least complicated. In order to overcome this problem, myocardial oxygen consumption must be considered in relation to the respective hemodynamic variables, i.e., stress-time integral, peak systolic stress, pressure-volume area, contraction velocity and others (see below). (3) Measurements of myocardial oxygen consumption — in contrast to hemodynamic measurements — need long periods of steady state conditions.


Dilate Cardiomyopathy Myocardial Blood Flow Coronary Sinus Myocardial Oxygen Consumption Dilate Ventricle 
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© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Christian J. F. Holubarsch
    • 1
  1. 1.Department of Cardiology & Angiology, Medizinische KlinikUniversity of FreiburgFreiburgGermany

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