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Molecular Mechanisms of Metal Toxicity and Carcinogenesis pp 159–171Cite as

Carcinogenic metals and NF-κB activation

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Part of the book series: Developments in Molecular and Cellular Biochemistry ((DMCB,volume 34))

Abstract

Epidemiological and animal studies suggest that several metals and metal-containing compounds are potent mutagens and carcinogens. These metals include chromium, arsenic, vanadium, and nickel. During the last two decades, chemical and cellular studies have contributed enormously to our understanding of the mechanisms of metal-induced pathophysiological processes. Although each of these metals is unique in its mechanism of action, some common signaling molecules, such as reactive oxygen species (ROS), may be shared by many of these carcinogenic metals. New techniques are now available to reveal the mechanisms of carcinogenesis in precise molecular terms. In this review, we focused our attentions on metal-induced signal transduction pathways leading to the activation of NF-KB, a transcription factor governing the expression of most early response genes involved in a number of human diseases. (Mol Cell Biochem 222: 159-171, 2001)

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Authors and Affiliations

  1. Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WI, USA

    Fei Chen, Min Ding, Vince Castranova & Xianglin Shi

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  1. Fei Chen
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  2. Min Ding
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  3. Vince Castranova
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  4. Xianglin Shi
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Editors and Affiliations

  1. Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, 26505, Morgantown, WV, USA

    Xianglin Shi , Vince Castranova  & Val Vallyathan ,  & 

  2. Occupational Safety and Health Administration, Washington DC, USA

    William G. Perry

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© 2001 Springer Science+Business Media New York

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Chen, F., Ding, M., Castranova, V., Shi, X. (2001). Carcinogenic metals and NF-κB activation. In: Shi, X., Castranova, V., Vallyathan, V., Perry, W.G. (eds) Molecular Mechanisms of Metal Toxicity and Carcinogenesis. Developments in Molecular and Cellular Biochemistry, vol 34. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0793-2_19

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  • DOI: https://doi.org/10.1007/978-1-4615-0793-2_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5242-6

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