Mathematical Models in the ICU: Dynamics, Infection Control and Antibiotic Resistance

  • Daren J. Austin
Part of the Perspectives on Critical Care Infectious Diseases book series (CCID, volume 5)


The rise in antibiotic resistant pathogens presents a considerable challenge to human health. Nowhere has this challenge been greater felt than in the hospital setting (1). Nosocomial infections caused by both gram negative organisms such as Klebsiella or gram-positives such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE), are becoming ever more difficult to treat. With the decreasing treatment options comes an ever-increasing reliance on control. To date, infection control practices such as hand washing and the cohorting of patients into distinct segregated Health Care Worker (HCW)-patient sub-units have tended to provide the cornerstone of control measures (3, 4, 5, 6, 7, 8, 9,10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23). Hand disinfection whether via the use of sinks or portable gel disinfectants is the focus of considerable attention, as the primary improvement in patient care. Cohorting has to a lesser extent also come under scrutiny, with a number of studies attempting to estimate the effectiveness of segregating infected patients and their carers from susceptible patients.


Respiratory Syncytial Virus Infection Control Neonatal Intensive Care Unit Reproductive Number Vancomycin Resistant Enterococcus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Daren J. Austin
    • 1
  1. 1.Norfolk Place, London W2 1PGImperial College School of MedicineUK

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