Carbon Monoxide and Iron, by-Products of Heme Oxygenase, Modulate Vascular Endothelial Growth Factor Synthesis in Vascular Smooth Muscle Cells

  • Józef Dulak
  • Roberto Motterlini
  • Ihor Huk
  • Otmar Pachinger
  • Franz Weidinger
  • Alicja Józkowicz


Vascular endothelial growth factor (VEGF; VEGF-A) is a major player in angiogenesis (for review see ref. 1). Enhancement of VEGF expression is mediated by hypoxia, inflammatory cytokines and some growth factors.1


Nitric Oxide Vascular Endothelial Growth Factor Vascular Smooth Muscle Cell Heme Oxygenase Vascular Endothelial Growth Factor Gene 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Józef Dulak
    • 1
    • 4
  • Roberto Motterlini
    • 2
  • Ihor Huk
    • 3
  • Otmar Pachinger
    • 1
  • Franz Weidinger
    • 1
  • Alicja Józkowicz
    • 3
    • 4
  1. 1.Division of CardiologyInnsbruck UniversityAustria
  2. 2.Vascular Biology Unit Department of Surgical ResearchNorthwick Park Institute for Medical ResearchHarrowUK
  3. 3.Department of Vascular SurgeryUniversity of ViennaAustria
  4. 4.Department of Cell Biochemistry, Institute of Molecular BiologyJagiellonian UniversityKrakowPoland

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