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Dynamic Surface Activity of Biological Fluids, Ophthalmic Solutions and Nanostructures

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Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 506)

Abstract

Various fluids including tears, pulmonary surfactant and synovial fluid lubricate the surfaces of the body. All have a similar function in that they act as boundary lubricants to prevent focal adhesions and minimize transmittance of shear forces.1 These fluids also exhibit some remarkable similarities in composition in that they all contain a phospholipid, dipalmitoylphosphatidylcholine, in combination with an amphipathic apoprotein or lipocalin to organize the lipid into lamellar sheets. The challenge in producing replacements for these fluids in treating lubricity deficiency diseases such as dry eye, respiratory distress syndrome and arthritis is not in replacing the phospholipid, which is readily available in synthetic form, but in replacing the apoprotein component.

Keywords

  • Ocular Surface
  • Pepsin Digestion
  • Ocular Surface Disease
  • Keratoconjunctivitis Sicca
  • Lacrimal Duct

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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© 2002 Kluwer Academic/Plenum Publishers

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Tonge, S., Rebeix, V., Young, R., Tighe, B. (2002). Dynamic Surface Activity of Biological Fluids, Ophthalmic Solutions and Nanostructures. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_83

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  • DOI: https://doi.org/10.1007/978-1-4615-0717-8_83

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5208-2

  • Online ISBN: 978-1-4615-0717-8

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