The Tear Film and Defense Against Infection
Our research program concerns the pathogenesis of bacterial corneal infection. We are studying the early events occurring when bacteria interact with the corneal surface, since it is these events that determine whether infection ensues or if the cornea can resist disease. Our long-term goals are two-fold: (1) to understand why certain factors, such as contact lens wear or preexisting trauma/disease, promote infection, and (2) to develop new approaches for prevention and therapeutics. How our research goals relate to tear film homeostasis is the subject of this paper.
KeywordsBurning Migration Fluorescein Hyaluronate Keratoconjunctivitis
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- 3.R. C. Andika, C. Wu, and S. M. J. Fleiszig. Chronic cytotoxicity induced by invasive Pseudomonas aeruginosa is invasion dependent and involves ExsA. Invest Ophthalmol Vis Sci. 39: S143 (1998).Google Scholar
- 5.S. M. J. Fleiszig, J. P. Wiener-Kronish, H. Miyazaki, V. Vallas, K. E. Mostov, D. Kanada, T. Sawa, T. S. Yen, and D. W. Frank. Pseudomonas aeruginosa-mediated cytotoxicity and invasion correlate with distinct genotypes at the loci encoding exoenzyme S. Infect Immun. 65: 579 (1997).PubMedPubMedCentralGoogle Scholar
- 10.R. Ramphal, M. T. McNiece, and F. D. Polack. Adherence of Pseudomonas aeruginosa to the injured cornea. A step in the pathogenesis of corneal infections. Ann Ophthalmol. 100:1956 (1981).Google Scholar