Androgen Influence on Gene Expression in the Meibomian Gland
Our previous research has demonstrated that the meibomian gland is an androgen target organ.1 This tissue contains androgen receptor mRNA, androgen receptor protein within acinar epithelial cell nuclei and the mRNAs for both Types 1 and 2 5±-reductase, an enzyme that converts testosterone and dehydroepiandrosterone into the potent androgen, 5a-dihydrotestosterone.2,3 Our studies also indicate that androgens, as well as gender, may influence gene expression in the rabbit and/or mouse meibomian glands.4,5 The purpose of this study was to identify androgen-regulated genes that may depend upon the presence of functional androgen receptors, and that may mediate the gender-related differences in gene expression in the meibomian gland.
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- 4.Steagall RJ, Yamagami H, Wickham LA, Sullivan DA. Androgen control of gene expression in the rabbit meibomian gland. Adv Exp Med Biol 2001; in press.Google Scholar
- 5.Yamagami H, Richards SM, Sullivan BD, Liu M, Steagall RJ, Sullivan DA. Gender-associated differences in gene expression of the meibomian gland. Adv Exp Med Biol 2001; in press.Google Scholar
- 15.Chung KW. Effects of tropic hormones on ultrastructure and synthesis of androgens in adrenals of male pseudohermaphroditeGoogle Scholar