Very recently, we discovered that women with Sjögren’s syndrome exhibit one of two distinct profiles in the polar lipid fraction of their meibomian gland secretions (Fig. 1). The first pattern is characterized by a single predominant peak eluting early on in the total ion current during HPLC analysis. The second pattern is characterized by multiple peaks spread over time. To begin to explore the mechanism(s) underlying these differences, we sought to determine whether the nutrient intake, and particularly the lipid consumption, of Sjögren’s syndrome patients may vary between those individuals expressing the “single” versus the “multiple” profile.
- Quartz Crystal
- Ocular Surface
- Lacrimal Gland
- Microbalance Technology
- Lacrimal System
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Sullivan BD, Evans JE, Dana MR, Sullivan DA. Impact of androgen deficiency on the lipid profiles in human meibomian gland secretions. Adv Exp Med Biol 2001; in press.
Sullivan BD, Evans JE, Sullivan RM, Schaumberg DA, Dana MR, Sullivan DA. Impact of hormone replacement therapy on the lipid profile of meibomian gland secretions in postmenopausal women. Manuscript submitted, 2001.
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© 2002 Kluwer Academic/Plenum Publishers
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Sullivan, B.D. et al. (2002). Correlations between Nutrient Intake and the Polar Lipid Profiles of Meibomian Gland Secretions in Women with Sjögren’s Syndrome. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_62
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