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Potency and Duration of Action of Synthetic P2Y2 Receptor Agonists on Schirmer Scores in Rabbits

  • Benjamin R. Yerxa
  • James G. Douglass
  • Pierre-Paul Elena
  • Thierry Caillaud
  • Thierry Amar
  • Catherine C. Redick
  • Ward M. Peterson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 506)

Abstract

P2Y2 receptors belong to the family of G-protein coupled receptors and are activated by nucleotides such as ATP and UTP.1,2 Activation of P2Y2 receptors (P2Y2-Rs) on various epithelial cell types enhances chloride, fluid and mucin secretion and thereby stimulates the body’s natural mucosal lubrication and clearance mechanisms.3,4 On the ocular surface, P2Y2-R mRNA is localized in various epithelial cells in the eyelid, cornea and conjunctiva. Previous work using conventional non-isotopic in situ hybridization techniques demonstrated localization of P2Y2-R mRNA in the palpebral conjunctiva of the eyelid, the epithelium of the lid margin and the meibomian gland; the corneal epithelium and adjacent bulbar conjunctiva, particularly the conjunctival goblet cells.5

Keywords

Case Group Ocular Surface Back Surface Lesion Development Sodium Fluorescein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic/Plenum Publishers 2002

Authors and Affiliations

  • Benjamin R. Yerxa
    • 1
  • James G. Douglass
    • 1
  • Pierre-Paul Elena
    • 2
  • Thierry Caillaud
    • 2
  • Thierry Amar
    • 2
  • Catherine C. Redick
    • 1
  • Ward M. Peterson
    • 1
  1. 1.Inspire PharmaceuticalsDurhamUSA
  2. 2.Iris PharmaLa GaudeFrance

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