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Nucleoside and Nucleotide Stimulation of Fluid Secretion in the Pigmented Rabbit Conjunctiva

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Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 506)

Abstract

Pigmented rabbit conjunctival epithelium is capable of secreting fluid at a rate of 4.3 ± 0.2 µl/hr/cm2.1 Active chloride secretion across the epithelium, which in the case of conjunctiva is modulated by second messengers such as cAMP,2 Ca2+,2 protein kinase C (PKC),2,3 and purine and pyrimidine nucleotides,4 is proposed to be a major driving force for this vectorial fluid movement.5 Several of these second messengers also stimulate fluid secretion across the corneal epithelium,6 retinal pigment epithelium,7 and tracheal epithelium.8 Further, we have reported previously that 8Br-cAMP is an efficient stimulant to fluid secretion in the pigmented rabbit conjunctiva.1

Keywords

  • Ocular Surface
  • Wear Time
  • Kinin Activity
  • Hereditary Angioedema
  • Contact Lens Wear

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© 2002 Kluwer Academic/Plenum Publishers

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Lee, V.H.L., Kulkarni, A.A., Shiue, M.H.I. (2002). Nucleoside and Nucleotide Stimulation of Fluid Secretion in the Pigmented Rabbit Conjunctiva. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_34

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  • DOI: https://doi.org/10.1007/978-1-4615-0717-8_34

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