Effects of Preganglionic Parasympathetic Denervation on the Rabbit Lacrimation

  • Hiroshi Toshida
  • Roger W. Beuerman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 506)

Abstract

Lacrimal gland fluid secretion is under neural control. Parasympathetic nerve fibers, with preganglionic origins in the seventh cranial nerve, innervate the lacrimal gland, and the secretory action and signal transduction of acinar cells of this gland are well known.1–4 Although the importance of parasympathetic control of lacrimation is recognized, few basic studies have investigated the function of ganglionic control as a secretomotor neural system in secretion of tear fluid in vivo.5 In the present study, the effects of acute severing of the preganglionic parasympathetic nerve in normal rabbit produced a dry eye condition with rapid onset.

Keywords

Hydrate Fluorescein 

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References

  1. 1.
    M.E. Stern, R.W. Beuerman, R.I. Fox, J. Gao, A.K. Mircheff, S.C. Pflugfelder. The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea 17:584–9 (1998).CrossRefPubMedGoogle Scholar
  2. 2.
    Dartt DA. Regulation of tear secretion. Adv Exp Med Biol. 350:1–9 (1994).CrossRefPubMedGoogle Scholar
  3. 3.
    S.L. Ruskin. Control of tearing by blocking the nasal ganglion. Arch Ophthalmol. 4:208–11 (1930).CrossRefGoogle Scholar
  4. 4.
    G.L. Ruskell. Changes in nerve terminals and acini of the lacrimal gland and changes in secretion induced by autonomic denervation. Z Zellforsch Mikrosk Anat. 94:261–81 (1969).CrossRefPubMedGoogle Scholar
  5. 5.
    H. Toshida, R.W. Beuerman. Effects of pre-ganglionic, parasympathetic denervation on tear flow and goblet cell function in the rabbit Invest Ophthalmol Vis Sci. 41:s64 (2000).Google Scholar
  6. 6.
    O.P. van Bijsterveld. Diagnostic tests in the sicca syndrome. Arch Ophthalmol. 82:10–4 (1969).CrossRefPubMedGoogle Scholar
  7. 7.
    R.W. Beuerman, L. Pedroza. Ultrastructure of human cornea. Microsc Res Tech. 33:320–335 (1996).CrossRefPubMedGoogle Scholar
  8. 8.
    D. Maitchouk, R.W. Beuerman. Tear production after unilateral removal of the main lacrimal gland in squirrel monkeys. Arch Ophthalmol. 188:246–52 (2000).CrossRefGoogle Scholar

Copyright information

© Kluwer Academic/Plenum Publishers 2002

Authors and Affiliations

  • Hiroshi Toshida
    • 1
  • Roger W. Beuerman
    • 1
  1. 1.Lion’s Eye Research Laboratories, Laboratory for the Molecular Biology of the Ocular SurfaceLouisiana State University Eye CenterNew OrleansUSA

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