Abstract
Activation of P2Y2 receptors in various tissues results in secretion of ions, fluid and mucin. In situ hybridization experiments on fresh primate tissue confirm the presence of mRNA coding for the gene expression of the P2Y2 receptor in the conjunctiva and the meibomian gland. Topical ocular administration of nucleotides causes increased chloride and mucin secretion, as well as fluid transport. These pharmacologic findings lead to the hypothesis that P2Y2 receptor agonists may have therapeutic efficacy in diseases of impaired ocular hydration.
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References
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© 2002 Kluwer Academic/Plenum Publishers
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Yerxa, B.R., Mundasad, M., Sylvester, R.N., Gorden, J.C., Cooper, M., Kellerman, D.J. (2002). Ocular Safety of Ins365 Ophthalmic Solution, a P2y2 Agonist, in Patients with Mild to Moderate Dry Eye Disease. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_180
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DOI: https://doi.org/10.1007/978-1-4615-0717-8_180
Publisher Name: Springer, Boston, MA
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