Abstract
Many tear components regulate ocular surface epithelial cell proliferation, differentiation and maturation, and are therefore critical in maintaining the ocular surface. Lack of either basic or reflex tearing results in severe dry eye conditions. Sjogren’s syndrome (SS) dry eye involves decreased reflex tearing. When treating severe dry eye, the primary goals are to reverse ocular surface desiccation and effect and preserve the stability of the tear component. Since many ocular surface regulatory components, including vitamin A and growth factors such as epidermal growth factor and TGF-13, are also present in serum, it is not surprising autologous serum is an effective treatment for severe SS and Stevens-Johnson syndrome dry eye. In this study, we confirm the efficacy of autologous serum treatment for severe dry eye.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
K. Tsubota, The importance of the Schirmer test with nasal stimulation, Am J Ophthalmol. 111:106–108 (1991).
Y. Ohashi, M. Motokura, Y. Kinoshita et al., Presence of epidermal growth factor in human tears,Invest Ophthalmol Vis Sci. 30: 1879–1887 (1989).
G. Van Setten, T. Tervo, K. Tervo et al., Epidermal growth factor (EGF) in ocular fluids: presence,origin and therapeutical concentration, Acta Ophthalmol. 202: 54–59 (1992).
R. Fox, R. Chan, J. Michelson et al., Beneficial effects of artificial tears made with autologous serum in patients with keratoconjunctivitis sicca, Arthritis Rheum. 27: 459–461 (1984).
K. Tsubota, E. Goto, H. Fujita et al., Treatment of dry eye by autologous serum application in SjOgren’s syndrome, Br J Ophthalmol . 83: 390–395 (1999).
K. Tsubota, E. Goto, S. Shimmura et al., Treatment of persistent corneal epithelial defect by autologous serum application, Ophthalmology. 106: 1984–1989 (1999).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Kluwer Academic/Plenum Publishers
About this chapter
Cite this chapter
Takamura, E., Shinozaki, K., Hata, H., Yukariand, J., Hori, S. (2002). Efficacy of Autologous Serum Treatment in Patients with Severe Dry Eye. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_179
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0717-8_179
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5208-2
Online ISBN: 978-1-4615-0717-8
eBook Packages: Springer Book Archive