Abstract
The preocular tear film is composed of an aqueous phase containing mucins and dissolved proteins and a thin external lipid layer. The lipid layer slows aqueous evaporation and protects the ocular surface from environmental irritants. The lacrimal glands supply the bulk of the ocular tear fluid phase, as well as many dissolved proteins. The meibomian glands of the eyelid secrete the lipids. Harderian glands of non-primate vertebrates secrete proteins and lipids.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
S.G. Remington, P.H. Lima, and J.D. Nelson, Pancreatic lipase-related protein 1 (PLRP1) mRNA in female mouse lacrimal gland, Invest Ophthalmol Vis Sci. 40:1081 (1999).
T.J. Nevalainen, H.J. Aho, and H. Peuravuori, Secretion of group 2 phospholipase A2 by lacrimal glands, Invest Ophthalmol Vis Sci. 35:417 (1994).
C.C. Lee and C.T. Caskey, cDNA cloning using degenerate primers, in: PCR Protocols: A Guide to Methods and Applications, M.A. Innis, D.H. Gelfand, J.J. Sninsky and T.J. White, eds., Academic Press, Inc., San Diego, CA (1990).
W.A. Hide, L. Chan, and W.-H. Li, Structure and evolution of the lipase superfamily, J Lipid Res. 33:167 (1992).
T. Compton, Degenerate primers for DNA amplification, in: PCR Protocols: A Guide to Methods and Applications, M.A. Innis, D.H. Gelfand, J.J. Sninsky and T.J. White, eds., Academic Press, Inc., San Diego (1990).
N.G. Shoham, T. Arad, R. Rosin-Abersfeld, P. Mashiah, A. Gazit, and A. Yaniv, Differential display assay and analysis, BioTechniques. 20:182 (1996).
S.F. Altschul, W. Gish, W. Miller, E.W. Myers, and D.J. Lipman, Basic logical alignment search tool, J Mol Biol. 215:403 (1990).
K.-i. Hirata, H.L. Dichek, J.A. Cioffi, et al., Cloning of a unique lipase from endothelial cells extends the lipase gene family, J Biol Chem. 274:14170 (1999).
T. Sato, J. Aoki, Y. Nagai, et al., Serine phospholipid-specific phospholipase A that is secreted from activated platelets: a new member of the lipase family, J Biol Chem. 272:2192 (1997).
L. Camps, M. Reina, M. Llobera, S. Vilaró, and T. Olivecrona, Lipoprotein lipase: cellular origin and functional distribution, Am J Physiol. 258:C673 (1990).
U. Beisiegel, New aspects on the role of plasma lipases in lipoprotein catabolism and atherosclerosis, Atherosclerosis. 124:1 (1996).
B. Nagyová and J.M. Tiffany, Components responsible for the surface tension of human tears, Curr Eye Res. 19:4 (1999).
J.P. McCulley and W. Shine, A compositional based model for the tear film lipid layer, Trans Am Ophthalmol Soc. 45:79 (1997).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Kluwer Academic/Plenum Publishers
About this chapter
Cite this chapter
Remington, S.G., Nelson, J.D. (2002). Lipase mRNAs Expressed in Lacrimal and Harderian Glands. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_15
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0717-8_15
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5208-2
Online ISBN: 978-1-4615-0717-8
eBook Packages: Springer Book Archive