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Intramuscular Force Transmission

  • Philip Sheard
  • Angelika Paul
  • Marilyn Duxson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 508)

Abstract

The architectural form of skeletal muscle, the pattern of activity/usage between neighbouring fibres, and the pathways for lateral and lengthwise tension delivery are all of interest in understanding muscle function and dysfunction. We have attempted to contribute to understanding of intramuscular force transmission by investigating the functional relationships between coactive motor units, and by examining the detailed molecular and morphological features at sites of tension transfer. We found that tension delivery is modulated by interaction between active and inactive fibres, that many muscle fibre terminations feature structural coupling between fibres, and that sites of tension delivery feature a variety of proteins including acetylcholinesterase, NCAM, dystrophin and two splice variants of the a7 integrins. We conclude that structural and molecular pathways exist to deliver force within, along, and between muscle fibres, and that the quality/quantity of tension delivered from any single fibre is at least partly a consequence of whether its neighbouring fibres are synchronously coactive.

Keywords

Motor Unit Mammalian Skeletal Muscle Myotendinous Junction Lateral Transmission Neighbouring Fibre 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Clamann, H. P., and Schelhorn, T. B., 1988, Nonlinear force addition of newly recruited motor units in the cat hindlimbMuscle and Nerve II1079–1089.CrossRefGoogle Scholar
  2. Emonet-Dénand, F., Laporte, Y. and Proske, U., 1990, Summation of tension in motor units of the soleus muscle of the catNeuroscience Letters116,112–117.PubMedCrossRefGoogle Scholar
  3. Gans, C., and Gaunt, A. S., 1991, Muscle architecture in relation to functionJournal of Biomechanics42, 53–65.CrossRefGoogle Scholar
  4. Gaunt, A. S., and Gans, C., 1992, Serially arranged myofibres: An unappreciated variant in muscle architectureExperientia48, 864–868.CrossRefGoogle Scholar
  5. Hill, A. V., 1951, The effect of series compliance on the tension developed in a muscle twitchProceedings of the Royal Society of London Series B: Biological Sciences138, 325–329.CrossRefGoogle Scholar
  6. Huijing, P. A., 1999, Muscle as a collagen fiber reinforced composite: a review of force transmission in muscle and whole limbJournal of Biomechanics32, 329–345.PubMedCrossRefGoogle Scholar
  7. Loeb, G., Pratt, C., Chanaud, C., and Richmond, F., 1987, Distribution and innervation of short, interdigitated muscle fibres in parallel-fibred muscles of the cat hindlimbJournal of Morphology191, 1–15.PubMedCrossRefGoogle Scholar
  8. Monti, R. J., Roy, R. R., and Edgerton, V. R., 2001, Role of motor unit structure in defining functionMuscle and. Nerve, 24, 848–866.CrossRefGoogle Scholar
  9. Monti, R. J., Roy, R. R., Hodgson, J. A., and Edgerton, V. R., 1999, Transmission of forces within mammalian skeletal musclesJournal of Biomechanics32, 371–380.PubMedCrossRefGoogle Scholar
  10. Patel, T. J., and Lieber, R. L., 1997, Force transmission in skeletal muscle: from actomyosin to external tendonsExercise and Sport Sciences Reviews25, 321–363.PubMedCrossRefGoogle Scholar
  11. Paul, A. C., 2001, Muscle length affects the architecture and pattern of innervation differently in leg muscles of mouse, guinea pig, and rabbit compared to those of human and monkey musclesAnatomical Record262, 301–309.PubMedCrossRefGoogle Scholar
  12. Pratt, C. A., and Loeb, G. E., 1991, Functionally complex muscles of the cat hindlimb. I. Patterns of activation across sartoriusExperimental Brain Research85, 243–256.CrossRefGoogle Scholar
  13. Proske, U., and Morgan, D. L., 1984, Stiffness of cat soleus muscle and tendon during activation of part of muscleJournal of Neurophysiology52, 459–468.PubMedGoogle Scholar
  14. Sheard, P. W., 2000, Tension delivery from short fibers in long musclesExercise and Sport Sciences Reviews28, 51–56.PubMedGoogle Scholar
  15. Sheard, P.W., McHannigan, P., and Duxson, M.J., 1999, Single and paired motor unit performance in skeletal muscles: Comparison between simple and series-fibred muscles from the rat and the guinea pigBasic and Applied Myology9, 79–87.Google Scholar
  16. Street, S.F., 1983, Lateral transmission of tension in frog myofibers: A myofibrillar network and transverse cytoskeletal connections are possible transmittersJournal of Cellular Physiology114, 346–364.PubMedCrossRefGoogle Scholar
  17. Tidball, J.G., 1991, Force transmission across muscle cell membranesJournal of Biomechanics2451, 43–52.CrossRefGoogle Scholar
  18. Troiani, D., Filippi, G.M., and Bassi, F.A., 1999, Nonlinear tension summation of different combinations of motor units in the anesthetized cat peroneus longus muscleJournal of Neurophysiology81, 771–780.PubMedGoogle Scholar
  19. Young, M., Paul, A., Rodda, J., Duxson, M., and Sheard, P., 2000, Examination of intrafascicular muscle fiber terminations: Implications for tension delivery in series-fibered musclesJournal of Morphology245, 130–145.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Philip Sheard
    • 1
  • Angelika Paul
    • 2
  • Marilyn Duxson
    • 1
    • 2
  1. 1.Department of PhysiologyOtago School of Medical Sciences, University of OtagoDunedinNew Zealand
  2. 2.Dept. of Anatomy and Structural BiologyOtago School of Medical Sciences, University of OtagoDunedinNew Zealand

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