Tumor immunity in mice immunized with fibroblasts transfected with tumor DNA
Accumulating evidence from multiple sources’ indicates that cancer cells form unique tumor associated antigens (TAAs). Under appropriate circumstances, they can become the targets of immune-mediated attack. Immunization of tumor-bearing animals, and patients, with tumor vaccines can stimulate anti tumor immune responses2’3leading to tumor rejection.
KeywordsSquamous Cell Carcinoma Cell Anti Tumor Immunogenic Property Melanoma Associate Antigen Small Tumor Burden
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- 4.Cavallo, F., Pierro, F.D., Giovarelli, M., Gulino, A., Vacca, A., Stoppacciaro, A., Fomi, M., Modesti, A., and Fomi, G. Protective and curative potential of vaccination with interleukin-2-gene-transfected cells from a spontaneous mouse mammary adenocarcinoma. Cancer Res. 53: 5067–5070, 1993.PubMedGoogle Scholar
- 6.Mullen, C.A., Coale, M.M., Levy, A.T., Stetler-Stevenson, W.G., Liotta, L.A., Brandt, S., and Blaese, R.M. Fibrosarcoma cells transduced with the IL-6 gene exhibit reduced tumorigenicity, increased immunogenicity, and decreased metastatic potential. Cancer Res. 52: 6120–6124, 1992.Google Scholar
- 7.Townsend S. E. and Allison, J.P. 1993. Tumor rejection after direct costimulation of CD8+T cells by B7 transfected melanoma cells Science 259:368.Google Scholar
- Geraghty PJ, Fields RC, Mule JJ. Vaccination with tumor-pulsed splenic dendritic cells mediates immunity to poorly-immunogenic tumor. Surg. Forum 47: 459–461, 1996.Google Scholar
- 11.Boczkowski D, Nair SK, Nam JH, Lyerly HK, Gilboa E. Induction of tumor immunity and cytotoxic T lymphocyte responses using dendritic cells transfected with messenger RNA amplified from tumor cells. Cancer Res. 2000 Feb 15;61(4):1028–34.Google Scholar
- 14.deZoeten, E.F., Carr-Brendel, V., Cohen, E.P. Resistance to melanoma in mice immunized with semiallogeneic fibroblasts transfected with DNA from mouse melanoma cells.J. Immuno161: 2915–2922, 1998.Google Scholar