Glycodendrimeric ligands of C-type lectin receptors as therapeutic agents in experimental cancer

  • Miloslav Pospišil
  • Luca Vannucci
  • Anna Fišerova
  • Katherina Krausova
  • Ondrej Horvath
  • Vladimir Křen
  • Franco Mosca
  • Thisbe K. Lindhorst
  • Kashinath Sadalapure
  • Karel Bezouška
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 495)

Abstract

The increased knowledge about the receptor-ligand relationships of the cytotoxic effector cells is suggesting modalities for new systems of immunomodulation. The lectin receptors on natural killer cells (NK) and their recognition of carbohydrate ligands are part of these new perspectives.

Keywords

Carbohydrate Oncol Oligosaccharide Penta Mannose 

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References

  1. 1.
    Pospíšil M, Vannucci L, Horváth O, Fišerova A, Krausová A, Bezouška K. and Mosca F: Cancer immunomodulation by carbohydrate ligands for the lymphocyte receptor (NKR-Pl). Intern J Oncol 16: 267–276, 2000.Google Scholar
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    Bezouška K., Křen V., Kieburg C., Lindhorst T.K.: GleNAc-terminated glycodendrimers form defined precipitates with the soluble dimeric receptor of rat natural killer cells, sNKR-PIA. FEBS Lett. 426: 243–247,1998.PubMedCrossRefGoogle Scholar
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    Černy J., Fišerová A., Horváth O.,Bezouška K., Pospíšil M., Horejši V.: Association of human NK cell surface receptors NKR-Pl and CD94 with Src-family proteine kinases. Immunogenetics 46(3):231–6, 1997.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Miloslav Pospišil
    • 1
  • Luca Vannucci
    • 2
  • Anna Fišerova
    • 1
  • Katherina Krausova
    • 1
  • Ondrej Horvath
    • 1
  • Vladimir Křen
    • 1
  • Franco Mosca
    • 2
  • Thisbe K. Lindhorst
    • 3
  • Kashinath Sadalapure
    • 3
  • Karel Bezouška
    • 1
  1. 1.Institute of Microbiology, Div. Immunology, Lab. Natural Cell ImmunityAcademy of Sciences of the Czech RepublicPragueItaly
  2. 2.Dpt. Oncology, Transplantation and New Technologies in Medicine, Div. General SurgeryUniversity of PisaItaly
  3. 3.Institute of Organic ChemistryChristiana Albertina University of KielGermany

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