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CRTH2: marker for the detection of human Th2 and Tc2 cells

  • Lorenzo Cosmi
  • Francesco Annunziato
  • Grazia Galli
  • Roberto Manetti
  • Enrico Maggi
  • Sergio Romagnani
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 495)

Abstract

Thl and Th2 cells represent two extremely polarized forms of the specific CD4+ Th cell-mediated immune response. Murine Thl cells secrete interleukin IL-2, TNF-ß and IFN-y, promoting cell-mediated immunity to intracellular pathogens, whereas Th2 cells produce IL-4, IL-5, IL-6, IL-10 and IL-13, which are mainly involved in the humoral immunity to parasites. Although human T-cell clones with similar characteristics exist, a better definition of Thl/Th2 cells may rest on their ability to produce IFN-y, but not IL-4 (Thl) or IL-4 but not IFN-y (Th2), respectively.

Keywords

Atopic Dermatitis Chemokine Receptor CCR4 Expression Lymphocyte Activation Gene Intracellular Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Lorenzo Cosmi
    • 1
  • Francesco Annunziato
    • 1
  • Grazia Galli
    • 1
  • Roberto Manetti
    • 1
  • Enrico Maggi
    • 1
  • Sergio Romagnani
    • 1
  1. 1.Department of Internal Medicine, Section of Clinical Immunology, Allergy and Respiratory DiseasesUniversity of FlorenceItaly

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