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Abstract

Statins (inhibitors of HMG-ConA reductase) are widely used as cholesterol-lowering agents and have beneficial action in patients with complications of atherosclerosis (coronary disease). In addition, recent data indicate that they can also modulate a variety of other biological processes inhibiting neointimal proliferation, reducing inflammation and stimulating osteogenesis (1 2 3). Moreover, our preliminary studies point to the role of statins as potential immunosuppressive agents (4). In this report, we confum and extend those initial observations.

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References

  1. Vaughan, C.J., Murphy, M.B. and Buckley, B.M. 2000, Statins do more than just lower cholesterol. Lancet 348:1079.

    Article  Google Scholar 

  2. Senior, K. 2000, The hidden potential for statins. Lancet 356:1905.

    Article  Google Scholar 

  3. Rogers, M.J. 2000, Statins: lower lipid and better bones? Nature Medicine 6:21.

    Article  PubMed  CAS  Google Scholar 

  4. Górski, A., Orlowska A., Nowaczyk M., et al. 1999, Statins inhibit T-cell interactions with elastin. Transplant.Proc. 31:828–829.

    Article  PubMed  Google Scholar 

  5. Górski, A., Grieb, P., Korczak-Kowalska, G., et al. 1993, Cladribine (2-chlorodeoxyadenosine, CDA): an inhibitor of human B and T cell activation in vitro. Immunopharmacology 26:197–202.

    Article  PubMed  Google Scholar 

  6. Imiela, J., Korczak-Kowalska, G., Malecki R., et al. 1993, Immunomodulatory action of human recombinant erythropoietin in man. Immunology Letters 35:271–276.

    Article  PubMed  CAS  Google Scholar 

  7. Górski, A., W4sik, M., Stepieñ-Sopniewska, B. et al. 1991, Heparin and platelet interactions influence alloantigen-induced proliferative responses of human T lymphocytes and immunoglobulin synthesis in vitro. Immunology Letters 28:161–166.

    Article  PubMed  Google Scholar 

  8. Ito, M., Watanabe, M., Kamiya H., and Sakurai, M. 1997, Changes in intracellular cytokine levels in lymphocytes induced by measles virus. Clin.Immun.Immunopathol. 83:281–286.

    Article  CAS  Google Scholar 

  9. Jo, E.K., Kim, J.K. and Lim, J.H. 2000, Dysregulated production of interferon-gamma, interleukin-4 and interleukin-6 in early tuberculosis patients in response to antigen 85B of Mycobacterium tuberculosis. Scand.J.Immunol. 51:209–217.

    Article  PubMed  CAS  Google Scholar 

  10. Górski, A., Castronovo, V., Stepieñ-Sopniewska, B. et al. 1994, Depressed immune surveillance against cancer: role of deficient T cell:extracellular matrix interactions. Cell Adhesion Com. 2:225–233.

    Article  Google Scholar 

  11. Korczak-Kowalska, G., Nowaczyk, M., Stepiefi-Sopniewska, B. et al. 1997, T-cell interactions with the extracellular matrix proteins and endothelium in chronic renal allograft rejection. Transplant.Proc.29:1057–1059.

    Article  PubMed  CAS  Google Scholar 

  12. Rokosz, A., Meisel-Mikolajczyk, F., Malchar, C., Nowaczyk, M., Górski, A. 1999, Adhesion molecule expression stimulated by B.thetaiotaomicron cell-surface antigens. Arch.Immun. Ther. Exp. 47:169–175.

    CAS  Google Scholar 

  13. Kwak, B., Muthaupt, F., Myit, S. and Mach, F. 2000, Statins as a newly recognized type of immunomodulator. Nature Medicine 6:1399–1402.

    Article  PubMed  CAS  Google Scholar 

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Górski, A. et al. (2001). Statins as immunomodulatory drugs. In: Mackiewicz, A., Kurpisz, M., Żeromski, J. (eds) Progress in Basic and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 495. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0685-0_39

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  • DOI: https://doi.org/10.1007/978-1-4615-0685-0_39

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5194-8

  • Online ISBN: 978-1-4615-0685-0

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