Abstract
Statins (inhibitors of HMG-ConA reductase) are widely used as cholesterol-lowering agents and have beneficial action in patients with complications of atherosclerosis (coronary disease). In addition, recent data indicate that they can also modulate a variety of other biological processes inhibiting neointimal proliferation, reducing inflammation and stimulating osteogenesis (1 2 3). Moreover, our preliminary studies point to the role of statins as potential immunosuppressive agents (4). In this report, we confum and extend those initial observations.
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References
Vaughan, C.J., Murphy, M.B. and Buckley, B.M. 2000, Statins do more than just lower cholesterol. Lancet 348:1079.
Senior, K. 2000, The hidden potential for statins. Lancet 356:1905.
Rogers, M.J. 2000, Statins: lower lipid and better bones? Nature Medicine 6:21.
Górski, A., Orlowska A., Nowaczyk M., et al. 1999, Statins inhibit T-cell interactions with elastin. Transplant.Proc. 31:828–829.
Górski, A., Grieb, P., Korczak-Kowalska, G., et al. 1993, Cladribine (2-chlorodeoxyadenosine, CDA): an inhibitor of human B and T cell activation in vitro. Immunopharmacology 26:197–202.
Imiela, J., Korczak-Kowalska, G., Malecki R., et al. 1993, Immunomodulatory action of human recombinant erythropoietin in man. Immunology Letters 35:271–276.
Górski, A., W4sik, M., Stepieñ-Sopniewska, B. et al. 1991, Heparin and platelet interactions influence alloantigen-induced proliferative responses of human T lymphocytes and immunoglobulin synthesis in vitro. Immunology Letters 28:161–166.
Ito, M., Watanabe, M., Kamiya H., and Sakurai, M. 1997, Changes in intracellular cytokine levels in lymphocytes induced by measles virus. Clin.Immun.Immunopathol. 83:281–286.
Jo, E.K., Kim, J.K. and Lim, J.H. 2000, Dysregulated production of interferon-gamma, interleukin-4 and interleukin-6 in early tuberculosis patients in response to antigen 85B of Mycobacterium tuberculosis. Scand.J.Immunol. 51:209–217.
Górski, A., Castronovo, V., Stepieñ-Sopniewska, B. et al. 1994, Depressed immune surveillance against cancer: role of deficient T cell:extracellular matrix interactions. Cell Adhesion Com. 2:225–233.
Korczak-Kowalska, G., Nowaczyk, M., Stepiefi-Sopniewska, B. et al. 1997, T-cell interactions with the extracellular matrix proteins and endothelium in chronic renal allograft rejection. Transplant.Proc.29:1057–1059.
Rokosz, A., Meisel-Mikolajczyk, F., Malchar, C., Nowaczyk, M., Górski, A. 1999, Adhesion molecule expression stimulated by B.thetaiotaomicron cell-surface antigens. Arch.Immun. Ther. Exp. 47:169–175.
Kwak, B., Muthaupt, F., Myit, S. and Mach, F. 2000, Statins as a newly recognized type of immunomodulator. Nature Medicine 6:1399–1402.
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Górski, A. et al. (2001). Statins as immunomodulatory drugs. In: Mackiewicz, A., Kurpisz, M., Żeromski, J. (eds) Progress in Basic and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 495. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0685-0_39
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DOI: https://doi.org/10.1007/978-1-4615-0685-0_39
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