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Interleukin-1 system in testis — quantitative analysis

Expression of immunomodulatory genes in male gonad
  • Natalia Rozwadowska
  • Dorota Fiszer
  • Maciej Kurpisz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 495)

Abstract

There is a growing body of evidence suggesting that interleukin-1 and other cytokines may influence mammalian testis function. IL-la activity seems to be tissue specific, and it appears in literature as a testicular interleukin-1 (tIL-1)1. Its activity was detected both in testicular interstitium and seminiferous epithelium. Being secreted in para-or autocrine manner, IL-1 inhibits steroidogenesis in Leydig cells, what suggests the modulatory role of this cytokine in LH-dependent testosterone synthesis. Sertoli cells are also capable to produce IL-1. The level of interleukin-1 expression in these cells is distinctly connected with the intensity of DNA synthesis in gametogenic cells. Thus IL-1 could be a nutritional factor, important for activity of seminiferous epithelium. Its expression both in Sertoli and Leydig cells depends on the local concentrations of hCG, FSH and LH and the other cytokines (e.g. TNFa) or growth factors in testis. Hence, IL-1 appears as another element of regulatory network essential for maintenance of testis physiology.2

Keywords

Sertoli Cell Leydig Cell Seminiferous Epithelium Autocrine Manner SuperScript Reverse Transcriptase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Natalia Rozwadowska
    • 1
  • Dorota Fiszer
    • 1
  • Maciej Kurpisz
    • 1
  1. 1.Institute of Human GeneticPolish Academy of SciencesPoznanPoland

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