Coordination of interleukin-6 biology by membrane bound and soluble receptors

  • Stefan Rose-John
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 495)


On target cells IL-6 first binds to the IL-6 receptor (IL-6R). The complex of IL-6 and IL-6R associates with the signaltransducing membrane protein gp130, thereby inducing its dimerization and initiation of signaling. gp130 is expressed by all cells in the body whereas IL-6R is mainly expressed by hepatocytes, monocytes/macrophages and lymphocytes. A naturally occurring soluble form of the IL-6R (sIL-6R), which has been found in various body fluids, is generated by two independent mechanisms, limited proteolysis of the membrane protein and translation from an alternatively spliced mRNA2. Interestingly, the sIL-6R together with IL-6 stimulates cells which only express gp 13034a process which has been named transsignaling25. Recently, it has been shown that the sIL-6R strongly sensitizes target cells6. Early hematopoietic progenitor cells57many neural cells“, smooth muscle cells and endothelial cells’1among others, are only responsive to IL-6 in the presence of sIL-6R12.


Hematopoietic Progenitor Cell Soluble Receptor Lamina Propria Mononuclear Cell Soluble Cytokine Receptor Human Hematopoietic Progenitor Cell 
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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Stefan Rose-John
    • 1
  1. 1.Department of Biochemistry, Christian-Albrechts-Universität zu KielOslhausenstr. 40KielGermany

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