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Apoptosis and the Pathogenesis of Helicobacter pylori—Related Disease

  • Emilia Mia Sordillo
  • Steven F. Moss
Part of the Infectious Agents and Pathogenesis book series (IAPA)

Abstract

It is an unavoidable, but intriguing, fact that chronic colonization of the stomach by Helicobacter pylori has no obvious deleterious consequences in most people. Approximately 10% of all infected individuals will develop a peptic ulcer, and half of those will commence a slow progression of pre-neoplastic changes that will ultimately lead to frank cancer in only a few.1 Why are certain individuals or populations predisposed to particular clinical outcomes after infection with H. pylori? The genetic background of the individual, the timing of first infection, environmental factors, and variations in the degree of bacterial pathogenicity all may contribute to the outcome of infection. One physiologic process that can be influenced by these variables is apoptosis, which when deregulated causes abnormal cell turnover, alterations in epithelial cell subpopulations, and changes in mucosal mass.

Keywords

Gastric Cancer Atrophic Gastritis Chronic Gastritis Malt Lymphoma Gastric Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Emilia Mia Sordillo
    • 1
    • 2
  • Steven F. Moss
    • 2
  1. 1.Department of Pathology & Laboratory Medicine USA
  2. 2.Department of MedicineSt. Luke’s-Roosevelt Hospital Center/Columbia University New YorkUSA

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