Dietary Induction of Phase II Enzymes: A Promising Strategy for Protection Against DNA-Reactive Intermediates in Man?
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Over the last decades, strong efforts have been made to identify chemoprotective agents in in vitro models with mammalian cells and in laboratory rodents and numerous molecular studies have been carried out to elucidate the mechanisms of prevention of DNA-damage and tumour formation by dietary constituents. Among the most important protective mechanisms identified are inhibition of activating-and induction of deactivating enzymes. Since humans differ substantially in their drug metabolism from laboratory rodents, it is unclear if animal data on chemoprotective agents can be extrapolated to man. The present article gives a brief overview on the impact of dietary factors on the activity and induction of important phase II enzymes in humans.
KeywordsEpoxide Hydrolase Laboratory Rodent Vegetable Diet Dietary Constituent Garden Cress
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