Hepatocarcinogenesis in the Context of Strain Differences in Energy Metabolism Between Inbred Strains of Mice (C57BL/6J and C3H/He)
Liver neoplasia in mice is one of the most frequent tumor target tissue endpoints observed in 2-year carcinogenicity studies of the US National Toxicology Program (NTP). B6C3F1 mice are the hybrids of male C3H/He, which are highly sensitive (hepatomas in 7291% at 14 months), and C57B1/6J females, which exhibit a low susceptibility to spontaneous and chemically induced hepatocarcinogenesis (Heston, 1963; Drinkwater and Bennett, 1991; Dragani et al. 1995; Wastl et al. 1998). Thus, the validity of mouse liver tumor endpoint in assessing the potential hazards of chemical exposure to humans is a controversial issue, since tumor susceptibility varies even within inbred strains of mice. Therefore our studies aimed to elucidate strain specifities that may modulate tumor development to improve the assessment for the relevance of mouse liver tumor induction in toxicological testing of chemicals.
KeywordsStrain Difference Mitochondrial Uncouple UCP2 Expression National Toxicology Program B6C3F1 Mouse
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