Inhibitory Effects of Roquefortine on Hepatic Cytochromes P450

  • C. Aninat
  • M. Delaforge
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 500)


Roquefortine, a cyclodipeptide derived from the diketopiperazine cyclo (TrpdehydroHis), is a secondary metabolite produced by some Penicillium species (1,2). P. roqueforti is considered as one of the most important fungal contaminants of carbonated beverages, beer, wine, meats, cheese, bread. It is reported to be among the predominant species in silage.


Liver Microsome Difference Spectrum Indole Alkaloid Penicillium Species Carbonate Beverage 
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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • C. Aninat
    • 1
  • M. Delaforge
    • 1
  1. 1.CEA Saclay, Département de la Recherche MédicaleService de Pharmacologie et d’ImmunologieFrance

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