Abstract
The material properties of our bones are crucial factors in their risk to fracture. With osteoporosis, bone strength is reduced due to a loss of bone mass and a diminution of structural integrity. Bone mass can be assessed easily and precisely. For this reason prediction of bone fracture risk is nowadays merely based on bone mineral density measurements. Bone mineral density alone, however, does not suffice to predict bone fracture risk for individual patients.1-3Improved risk prediction should include bone structure as well.4-8
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References
L. J. Melton, S. H. Kan, M. A. Frye, H. W. Wahner, W. M. O’Fallon, and B. L. Riggs, Epidemiology of vertebral fractures in womenAmerican J. Epidemiology129,1000–1012 (1989).
P. Rüegsegger, Bone density measurements, in:Osteoporosis: a guide to diagnosis and treatmentedited by S. Broil, S. Dambacher, and B. Karger, pp. 103–116 (1996).
A. I. Ahmed, G. M. Blake, J. M. Rymer, and I. Fogelman, Screening for osteopenia and osteoporosis: do to accepted normal ranges lead to overdiagnosis?Ost. Int.7, 432–438 (1997).
A. M. Partin, Implication of architecture for the pathogenesis and prevention of vertebral fractureBone13, 41–47 (1992).
B. D. Snyder, S. Piazza, W. T. Edwards, W. C. Hayes, Role of trabecular morphology in the etiology of age-related vertebral fracturesCalcif. Tissue Int.53-S1, 14–22 (1993).
C. Cooper, The epidemiology of fragility fractures: Is there a role for bone quality?Calcif. Tissue Int.53-S1, 23–26 (1993).
C. C. Johnston, C. W. Slemenda, Pathogenesis of osteoporosisBone17,19–22 (1995).
D. Ulrich, B. van Rietbergen, A. Laib, and P. Rüegsegger, The ability of 3-D structural indices to reflect mechanical aspects of trabecular boneBone25(1), 55–60 (1999).
S. J. Hollister, J. M. Brennan, and N. Kikuchi, A homogenization sampling procedure for calculating trabecular bone effective stiffness and tissue level stressJ. Biomech.27(4), 433–444 (1994).
B. van Rietbergen, A. Odgaard, J. Kabel, and R. Huiskes, Direct mechanics assessment of elastic symmetries and properties of trabecular bone architectureJ. Biomech.29(12), 1653–1657 (1996).
A. J. Ladd, J. H. Kinney, D. L. Haupt, and S. A. Goldstein, Finite-element modeling of trabecular bone: comparison with mechanical testing and determination of tissue modulusJ. Orthop. Res.16, 622–628 (1998).
L. A. Feldcamp, S. A. Goldstein, A. M. Partin, G. Jesion and M. Kleerekoper, The direct examination of three-dimensional bone architecture in vitro by computed tomographyJ. Bone Miner. Res.4, 311 (1989).
P. Rüegsegger, B. Koller, and R. Müller, A microtomographic system for the non-destructive evaluation of bone architectureCalcif. Tissue Int.58, 24–29 (1996).
U. Bonse, F. Busch, O. Gunnewig, F. Beckmann, R. Pahl, G. Delling, M. Hahn, and W. Graeff, 3D computed X-ray tomography of human cancellous bone at 8 microns spatial and I 0(-4) energy resolutionBone Miner.25, 25–38 (1994).
A. Odgaard, K. Andersen, F. Melsen, and H. J. G. Gundersen, A direct method for fast three-dimensional serial reconstruction, J. Microscopy, 159, 335–342 (1990).
J. D. Beck, B. L. Canfield, S. M. Haddock, T. J. Chen, M. Kothary, and T. M. Keaveny, Three dimensional imaging of trabecular bone using the computer numerically controlled milling TechniqueBone21(3), 281–287 (1997).
A. Laib, T. Hildebrand, H. J. Häuselmann, and P. Rüegsegger, Ridge Number Density: A new Parameter for in vivo Bone Structure AnalysisBone21, 541–546 (1997).
S. Majumdar, D. Newitt, A. Mathur, D. Osman, A. Gies, E. Chiu, J. Lotz, J. Kinney, and H. Genant, Magnetic resonance imaging of trabecular bone structure in the distal radius: relationship with X-ray tomographic microscopy and biomechanicsOsteoporos. Int.6, 376–385 (1996).
F. W. Wehrli, S. N. Hwang, J. Ma, H. K. Song, J. C. Ford, and J. G. Haddad, Cancellous bone volume and structure in the forearm: noninvasive assessment with MR microimaging and image processingRadiology206(2), 347–357 (1998).
R. Müller, T. Hildebrand and P. Rüegsegger, Non-invasive bone biopsy: a new method to analyse and display the three-dimensional structure of trabecular bonePhys. Med. Biol.39, 145–164 (1994).
D. Ulrich, B. van Rietbergen, A. Laib, and P. Rüegsegger, Bone density and microstructure - New methods to determine bone quality and fracture risk, in:Computer methods in biomechanics & biomedical engineering-2edited by J. Middleton, M. L. Jones and G. N. Pande, pp. 221–229 (1998).
W. Pistoia, B. van Rietbergen, A. Laib and P. Rüegsegger, High-Resolution 3D-pQCT Images can be an adequate basis for in-vivo MEE analysis of bone, accepted byJournal of Biomech. Eng.(2000).
D. Ulrich, B. van Rietbergen, A. Laib and P. Rüegsegger, 1999, Load transfer analysis of the distal radius from in vivo high-resolution CT-imaging, J. Biomech., 32(8), 821–828 (1999).
B. van Rietbergen, H. Weinans, R. Huiskes, and A. Odgaard, A new method to determine trabecular bone elastic properties and loading using micromechanical finite-element modelsJ. Biomech.28(1), 69–81 (1995).
B. van Rietbergen, W. Pistoia, D. Ulrich, R. Huiskes and P. Rüegsegger, 2000, Prediction of trabecular bone failure parameters using a tissue failure criterion and µFE analysisComp. Simul. & Model. In Medicine1–2, 98–101 (2000).
A. Kohlbrenner, S. Hämmerle, A. Laib, B. Koller, and P. Rüegsegger, Fast 3D multiple fan-beam CT SystemProceedings SPIE44–54 (1999).
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Pistoia, W., van Rietbergen, B., Eckstein, F., Lill, C., Lochmüller, E.M., Rüegsegger, P. (2001). Prediction of Distal Radius Failure with µFE Models Based on 3D-PQCT Scans. In: Majumdar, S., Bay, B.K. (eds) Noninvasive Assessment of Trabecular Bone Architecture and the Competence of Bone. Advances in Experimental Medicine and Biology, vol 496. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0651-5_15
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DOI: https://doi.org/10.1007/978-1-4615-0651-5_15
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