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Ectopeptidases pp 223-257 | Cite as

DPIV — Natural Substrates of Medical Importance

  • Ingrid de Meester
  • Christine Durinx
  • Paul Proost
  • Simon Scharpé
  • Anne-Marie Lambier

Abstract

In a continuing attempt to unravel the in vivo function of this abundant but highly regulated enzyme, the hydrolysis of bioactive peptides by DPIV has been studied extensively (Mentlein 1999). This chapter focuses on recent data concerning a number of human naturally occurring peptides that are cleaved by DPIV in vitro and that may be substrates in vivo. A summary of the kinetic parameters of the processing by DPIV can be found at the end of this chapter.

Keywords

Vasoactive Intestinal Peptide Pituitary Adenylate Cyclase Activate Polypeptide Gastric Inhibitory Polypeptide Dipeptidyl Peptidase Gastrin Release Peptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Ingrid de Meester
    • 1
  • Christine Durinx
    • 1
  • Paul Proost
    • 2
  • Simon Scharpé
    • 1
  • Anne-Marie Lambier
    • 1
  1. 1.Laboratory of Clinical BiochemistryUniversity of AntwerpAntwerpBelgium
  2. 2.Laboratory of Molecular Immunology, Rega Institute for Medical ResearchUniversity of LeuvenLeuvenBelgium

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