Abstract
Boron is an essential element for plants (Lovatt, 1985) and embryological development in fish (Rowe and Eckert, 1999) and frogs (Fort et al., 1999) does not proceed normally in the absence of extracellular boron. There is evidence that higher animals (Hunt and Idso, 1999; Armstrong et al., 2000) and humans (Hunt et al., 1997; Nielsen et al., 1992; Travers et al., 1990) require physiological amounts of boron to support normal biological functions. Despite the progress made in studies of boron essentiality for both plants and animals, the biochemical mechanisms responsible for the beneficial physiologic effects of boron across the phylogenetic spectrum are poorly understood. However, the unique nature of boron biochemistry suggests specific lines of investigation. This review summarises some of the progress made in understanding the essential roles of boron at the molecular level.
The U.S Department of Agriculture, Agricultural Research Service, Northern Plains Area, is an equal opportunity/affirmative action employer and all agency services are available without discrimination.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Albersheim, P., An, J., Freshour, G., Fuller, M.S., Guillen, R., Ham, K.S., Hahn, M.G., Huang, J., O’Neill, M., Whitcombe, A., et al., 1994, Structure and function studies of plant cell wall polysaccharides. Biochem. Soc. Trans. 22: 374–378.
Armstrong, T.A., Spears, J.W., Crenshaw, T. D., and Nielsen, F.H., 2000, Boron supplementation of a semipurified diet for weanling pigs improves feed efficiency and bone strength characteristics and alters plasma lipid metabolites. J. Nutr.139: 2575–2581
Bachovchin, W.W., Wong, W.Y.L., Farr-Jones, S., Shenvi, A.B., and Kettner, C.A., 1988,Nitrogen-15 NMR spectroscopy of the catalytic-triad histidine of a serine protease in peptide boronic acid inhibitor complexes. Biochem. 27:7689–7697.
Bauer, C.-A., and Pettersson, G., 1974, Effect of boric acid on the catalytic activity of Streptomyces griseus Protease 3. Eur. J. Biochem. 45: 473–477.
Bell, C.F., Beauchamp, R.D., and Short, E.L., 1986, A study of the complexes of borate ions and some cyclitols using 11B-N.M.R. spectroscopy. Carbohydrate Res. 147: 191–203.
Berezin, I.V., Vill, K.H., Martinek, K., and Yatsimirshii, A.K., 1967, Reversible inactivation of a-chymotrypsin resulting from interaction of Cu++ ions with the imidazole group of a histidine residue. Molek. Biol. 1: 719–728.
Berry, S.C. Fink, A.L., Shenvi, A.B., and Kettner, C.A., 1988, Interaction of peptide boronic acids with elastase: circular dichroism studies. Proteins: Structure, Function, and Genetics 4: 205–210.
Chen, T.S.S., Chang, C.-J., and Floss, H.G., 1979: Biosynthesis of the boron-containing macrodiolide antibiotic aplasmomycin. J. Am. Chem. Soc.101: 5826–5827.
Cotton, F.A., and Wilkinson, G., 1972, Advanced Inorganic Chemistry (Interscience Publishers, Div. of John Wiley & Sons, New York.
Coyle, T.D. and Stone, F.G.A., 1964, In Progress in Boron Chemistry, H. Steinberg, A. McCloskey, eds., Macmillan Co., New York, 1964, pp. 83–165.
Dugger, W.M., Humphreys, T.E., and Calhoun, B., 1957, The influence of boron on starch phosphorylase and its significance in translocation of sugars in plants. Plant Physiol 32: 364–370.
Fort, D.J. Stover, E.L., Strong, P.L., Murray, F.J., and Keen, C.L., 1999, Chronic feeding of a low boron diet adversely affects reproduction and development in Xenopus laevis. J. Nutr. 129: 2055–2060.
Garbett, K., Darnall, D.W., and Klotz, I.M., 1971, The effects of bound anions on the reactivity of residues in hemerythrin. Arch. Biochem. Biophys. 142: 455–470.
Gerrard, W., 1961, The Organic Chemistry of Boron. Academic Press, London.
Greenwood, N.N. and Earnshaw, A., 1984, Chemistry of the Elements, Pergamon Press, Oxford, Great Britain.
Greenwood, N.N., 1973, In: Comprehensive Inorganic Chemistry, J.J. Bailar, H. Emeléus, R. Nyholm, A. Trotman-Dickenson, eds., Pergamon Press Ltd., Oxford, 1973, pp. 665–990.
Gunther Sillero, M.A., and Caeselle, J.C, 1992, In Ap4A and other dinucleoside polyphosphates. A.G. McLennan, ed., CRC Press, Boca Raton, pp. 205–229.
Hausdorf, G., Krüger, K., Küttner, G., Holzhütter, H.-G., Frömmel, C, and Höhne, W.E., 1987, Oxidation of a methionine residue in subtilisin-type proteinases by the hydrogen peroxide/borate system- -an active site- directed reaction. Biochim. Biophys. Acta 952: 20–26.
Hu, H., Penn, S.G., Lebrilla, C.B., and Brown, P.H., 1997, Isolation and characterization of soluble B-complexes in higher plants. Plant Physiol. 113: 649–655.
Hunt, C.D. and Idso, J.P., 1999, Dietary boron as a physiological regulator of the normal inflammatory response: a review and current research progress. J. Trace Elem.Exp.Med. 12:221–233.
Hunt, C.D., Herbel, J.L., and Nielsen, F.H., 1997, Metabolic response of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations. Am. J. Clin. Nutr. 65: 803–813.
Johnson, S.L. and Smith, K.W., 1976, The interaction of borate and sulfite with pyridine nucleotides. Biochemistry 15: 553–559.
Kettner, C.A., and Shenvi, A.B., 1984, Inhibition of the serine proteases leukocyte elastase, pancreatic elastase, cathepsin G, and chymotrypsin by peptide boronic acids. J. Biol. Chem. 259: 15106–15114.
Kettner, C.A., Bone, R., Agard, D.A., and Bachovchin, W.W., 1988, Kinetic properties of the binding of alpha-lytic protease to peptide boronic acids. Biochem. 27: 7682–7688.
Kohno, J., Kawahata, T., Otake, T., Morimoto, M., Mori, H., Ueba, N., Nishio, M., Kinumaki, A., Komatsubara, S., and Kawashima, K., 1996, Boromycin, an anti-HIV antibiotic, Biosci. Biotechnol. Biochem. 60: 1036–1037.
Kolodny, N.H., and Collins, L.J., 1986, Proton and phosphorus-31 NMR study of the dependence of diadenosine tetraphosphate conformation on metal ions. J. Biol. Chem. 261: 14571–14577.
Kozarich, J.W., 1988, S-adenosylmethionine-dependent enzyme activation. Biofactors 1: 123–128.
Loomis, W.D., and Durst, R.W., 1991, Boron and cell walls. Curr. Topics Plant Biochem. Physiol. 10: 149–178.
Loomis, W.D. and Durst, R.W., 1992, Chemistry and biology of boron. BioFactors 3: 229–239.
Lovatt, C.J., 1985, Evolution of xylem resulted in a requirement for boron in the apical meristems of vascular plants. New Phytol. 99: 509–522.
Nielsen, F.H., Gallagher, S.K., Johnson, L.K., and Nielsen, E.J., 1992, Boron enhances and mimics some effects of estrogen therapy in postmenopausal women. J. Trace Elem. Exp. Med. 5: 237–246.
Ogilvie, A., 1992: In Ap4A and other dinucleoside polyphoshates. A.G. McLennan, ed., CRC Press, Boca Raton, pp. 229–275.
Power, P.P. and Woods, W.G., 1997, The chemistry of boron and its speciation in plants, Plant Soil 193:1–13.
Ralston, N.V.C., and Hunt, C.D., 2001, Diadenosine phosphates and S-adenosylmethionine: novel boron binding biomolecules detected by capillary electrophoresis. Biochim. Biophys. Acta (In press).
Raven, J.A., 1980, Short- and long-distance transport of boric acid in plants. New Phytol. 84: 231–249.
Rowe, R.I. and Eckhert, C.D., 1999, Boron is required for zebrafish embryogenesis. J. Exp. Biol. 202: 1649–1654.
Sato, K., Okazaki, T., Maeda, K., Maeda, K., and Okami, Y., 1978, New antibiotics, aplasmomycins B and C. J. Antibiotics 31: 632–635.
Schummer, D., Irschik, H., Reichenbach, H., and Höfle, G., 1994, Antibiotics from gliding bacteria, LVII. Tartrolons: new boron-containing macrodiolides from Sorangium cellulosum. Liebigs Ann. Chem. 1994: 283–289.
Scudi, J.V., Bastedo, W.A., and Webb, T.J., 1940, The formation of a vitamin B6-borate complex. J. Biol. Chem. 136: 399–406.
Smith, K.W. and Johnson, S.L., 1976, Borate inhibition of yeast alcohol dehydrogenase. Biochem. 15: 560–565.
Spivack, A.J., and Edmond, J.M., 1987, Boron isotope exchange between seawater and the oceanic crust. Geochim. Cosmochim. Acta 51: 1033–1043.
Thellier, M., Duval, Y., and Demarty, M., 1979, Borate exchanges of Lemna minor L. as studied with the help of the enriched stable isotopes and of a (n, alpha) nuclear reaction. Plant Physiol. 63: 283–288.
Travers, R.L., Rennie, G.C, and Newnham, R.E., 1990, Boron and arthritis: the results of a double-blind pilot study. J. Nutr. Med. 1: 127–132.
Van Duin, M., Peters, J.A., Kieboom, A.P.G., and Van Bekkum, H., 1984, Studies on borate esters I. The pH dependence of the stability of esters of boric acid and borate in aqueous medium as studied by 11B NMR. Tetrahedron 40: 2901–2911.
Weser, U. 1967, In: Structure and Bonding, C. Jorgensen, J. Neilands, R. Nyholm, D. Reinen, R. Williams, eds., Springer-Verlag, New York, pp. 160–180.
Zittle, C.A., 1951, In: Advances in Enzymology, F. Ford, ed., Interscience Publishers, New York, 1951, pp. 493–527.
Zubay, G., 1988, Biochemistry. Macmillan, New York.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Science+Business Media New York
About this chapter
Cite this chapter
Hunt, C.D. (2002). Boron-Binding-Biomolecules: a Key to Understanding the Beneficial Physiologic Effects of Dietary Boron from Prokaryotes to Humans. In: Goldbach, H.E., Brown, P.H., Rerkasem, B., Thellier, M., Wimmer, M.A., Bell, R.W. (eds) Boron in Plant and Animal Nutrition. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0607-2_3
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0607-2_3
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5155-9
Online ISBN: 978-1-4615-0607-2
eBook Packages: Springer Book Archive