Role of Non-Transferrin-Bound Iron in The Pathogenesis of Iron Overload and Toxicity

  • Pierre Brissot
  • Olivier Loréal
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 509)


Mammalian cells accumulate iron from two main circulating sources. The first one, which is the classical source, consists of iron bound to transferrin. The second one, identified by Hershko and colleagues1, is called Non-Transferrin-Bound Iron (NTBI). The latter source is increasingly acknowledged as being of primary importance in iron overload situations, due to its high uptake by parenchymal cells and its potential toxicity.


Iron Overload Transferrin Saturation Hepatic Iron Acute Iron Genetic Hemochromatosis 
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© Kluwer Academic/Plenum Publishers, New York 2002

Authors and Affiliations

  • Pierre Brissot
    • 1
  • Olivier Loréal
  1. 1.Service des Maladies du Foie et INSERM U-522Pontchaillou University HospitalRennesFrance

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