Skip to main content

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 503))

Abstract

It is an honor to have been chosen by the International Society for Research in Human Milk and Lactation to be the recipient of the Macy-György Award for Research in Human Milk and Lactation for the year 2000. The Award is of special significance because Icey Macy and Paul György were pioneers in research concerning human milk and lactation and because the Society is the leading organization that deals with research in this aspect of human biology.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. A.E. Hanson, H.F. Wiese, M. Lawlis, D.J.D. Adams, A.S. Goldman, and M.A. Baughan, Fat in diet of infants in relation to caloric consumption, growth, and serum levels for specific fatty acids. A.M.A. J. Dis. Child. 90:621 (1955).

    Google Scholar 

  2. A.S. Goldman, D.W. Anderson, W.A. Sellars, S. Saperstein, W.T. Kniker, and S.R. Halpern, Milk allergy. I. Oral Challenge with milk andisolated milk proteins in allergic children. Pediatrics 32:425–443 (1963).

    PubMed  CAS  Google Scholar 

  3. P. Ehrlich, Über Immunitat durch Verebung und Saugung. Z. Hug. InfektKr. 12:183–208 (1892).

    Google Scholar 

  4. J. Bordet, Les sérums hemolytiques, leurs antitoxines et les théories des sérums cytolytiques. Ann. Inst. Pasteur. 14:257–297 (1900).

    CAS  Google Scholar 

  5. J. Bordet and M. Mordet, M. Le pouvoir bactériolytique du colostrum et du lait. Comptes Rendus des Séaces de L’Acedemie des Sciences 179:1109–1113 (1924).

    CAS  Google Scholar 

  6. A Fleming, On a remarkable bacteriolytic element found in tissues and secretions. Proc. Roy Soc., London B93:306–317 (1922).

    Google Scholar 

  7. R.M. Woodbury, The relation between breast and artificial feeding and infant mortality. Am. J. Hyg. 2:668 (1922).

    Google Scholar 

  8. C.G. Grulee, H.N. Sanford, and P.H. Heron, Breast and artificially-fed infants. Influence on morbidity and mortality of twenty thousant infants. JAMA 103:735–739 (1934).

    Article  Google Scholar 

  9. C.G. Grulee, H.N. Sanford, and H. Schwartz, Breast and artificially-fed infants. A study of the age incidence in the morbidity and mortality in twenty thousand cases. JAMA 104:1986–1988 (1935).

    Article  Google Scholar 

  10. A.S. Goldman, The immunological system in human milk: the past - a pathway to the future, in: Advances in Nutritional Research,In Press.

    Google Scholar 

  11. P. György, A hitherto unrecognized biochemical difference between human milk and cow’s milk. Pediatrics 11:98–107 (1953).

    PubMed  Google Scholar 

  12. P. György, S. Dhanamitta, and E. Steers, Protective effects of human milk in experimental Staphylococcus infection. Science 137:338–340 (1962).

    Article  PubMed  Google Scholar 

  13. L.A Hanson, Comparative studies of the immune globulins of human milk and blood serum. Int. Arch Allergy 18:241–267 (1961).

    Article  PubMed  CAS  Google Scholar 

  14. A. Van Leeuwenhoek, Epistola 106. Arcana naturae detecta delphis batavorum. Apud Henricum a Krooneveld (1965).

    Google Scholar 

  15. C.W. Smith, and A.S. Goldman, The cells of human colostrum. I. In vitro studies of morphology and functions. Pediatr. Res. 2:103–109 (1968).

    CAS  Google Scholar 

  16. C.W. Smith, and A.S. Goldman, Interactions of lymphocytes and macrophages from human colostrum: Characteristics of the interacting lymphocyte. Res. J. Reticuloendothelial Soc. 8:91–104 (1970).

    CAS  Google Scholar 

  17. C.W. Smith, A.S. Goldman, and R.D. Yates, Interactions of lymphocytes and macrophages from human colostrum: Electron microscopic studies of the interacting lymphocyte. Exp. Cell Res. 69:409–415 (1971).

    Article  PubMed  CAS  Google Scholar 

  18. A.S. Goldman, and C.W. Smith, Host resistance factors in human milk. J. Pediatr. 82:1082–1090 (1973).

    Article  PubMed  CAS  Google Scholar 

  19. G.J. Murillo, and A.S. Goldman, The cells of human colostrum. II. Synthesis of IgA and Blc. Pediatr. Res. 4:71–75 (1970).

    CAS  Google Scholar 

  20. C.W. Smith, and A.S. Goldman, Macrophages from human colostrum: Multinucleated giant cell formation by phytohemagglutinin and concanavalin A. Exp. Cell Res. 66:310–317 (1971).

    Google Scholar 

  21. W.D. Dickey, H.B. Rudloff, A.S. Goldman, and F.C. Schmalstieg, Human uropod bearing lymphocytes: Isolation of a factor from human milk that abrogates the uropod inhibitory protein from human serum. Biochem. Biophys. 100:138–145 (1981).

    Article  CAS  Google Scholar 

  22. R.M. Goldblum, C. Garza, C.A. Johnson, B.L. Nichols, and A.S. Goldman, Human milk banking. I. Effects of container upon immunologic factors in mature milk. Nutrition Research 1:449–459 (1981).

    Article  Google Scholar 

  23. R.M. Goldblum, C. Garza, C.A. Johnson, B.L. Nichols, and A.S. Goldman, Human Milk banking. II. Relative stability of immunologic factors in stored colostrum. Acta Paediatr. Scand. 71:143–144 (1982).

    Article  PubMed  CAS  Google Scholar 

  24. R.M. Goldblum, C.W. Dill, T.B. Albrecht, E. Alford, C. Garza, and A.S. Goldman, Rapid high temperature treatment of human milk. J. Pediatr. 104:380–385 (1984).

    Article  PubMed  CAS  Google Scholar 

  25. A.S. Goldman, C. Garza, B. Nichols, C.A. Johnson, E. Smith, and R.M. Goldblum, The effects of prematurity upon the immunologic system in human milk. J. Pediatr. 101:901–905 (1982).

    Article  PubMed  CAS  Google Scholar 

  26. A.S. Goldman, C. Garza, C.A. Johnson, B.L. Nichols, and R.M. Goldblum, Immunologic factors in human milk during the first year of lactation. J. Pediatr. 100:563–567 (1982).

    Article  PubMed  CAS  Google Scholar 

  27. A.S. Goldman, R.M. Goldblum, and C. Garza, Immunologic components in human milk during the second year of lactation. Acta Paediatr. Scand. 72:461–462 (1983).

    Article  PubMed  CAS  Google Scholar 

  28. A.S. Goldman, C. Garza, C.A. Johnson, B.L. Nichols, and R.M. Goldblum, Immunologic components in human milk during weaning. Acta Paediatr. Scand. 72:133–134 (1983).

    Article  PubMed  CAS  Google Scholar 

  29. N.F. Butte, R.M. Goldblum, L.M. Fehl, K. Loftin, E.O. Smith, C. Garza, and A.S. Goldman, Daily ingestion of immunologic components in human milk during the first four months of life. Acta Paediatr. Scand. 73:296–301 (1984).

    Article  PubMed  CAS  Google Scholar 

  30. R.J. Schanler, R.M. Goldblum, C. Garza, and A.S. Goldman, Enhanced fecal excretion of secreted immune factors in very low birth weight infants fed fortified human milk. Pediatr. Res. 20:711–715 (1986).

    Article  PubMed  CAS  Google Scholar 

  31. A.S. Goldman, C. Garza, R.J. Schanler, and R.M. Goldblum, Molecular forms of lactoferrin in stool and urine from infants fed human milk. Pediatr. Res. 27:252–255 (1990).

    Article  PubMed  CAS  Google Scholar 

  32. T.W. Hutchens, et al:, Origin of intact lactoferrin and its DNA-binding fragments found in the urine of human milk-fed preterm infants. Evaluation of stable isotopic enrichment. Pediatr Res 29:243 (1991).

    Article  PubMed  CAS  Google Scholar 

  33. A.S. Goldman, and R.M. Goldblum, Immunologic system in human milk: characteristics and effects, in: Textbook of Gastroenterology and Nutrition In Infancy, edited by E. Lebenthal, - 2nd. Edition.(Raven Press, New York 1989) pp. 135–142.

    Google Scholar 

  34. R.G. Wyatt, and L.J. Mata, Bacteria in colostrum and milk of Guatemalan Indian women. J. Trop. Pediatr. 15:159–162 (1969).

    Article  PubMed  CAS  Google Scholar 

  35. L.J. Mata, J.J. Urrutia, and J.E. Gordon, Diarrhoeal disease in a cohort of Guatemalan village children observed from birth to age two years. Trop. Geogr. Med. 19:247–257 (1967).

    PubMed  CAS  Google Scholar 

  36. L.J. Mata, et al., Shigella infection in breast-fed Guatemalan Indian neonates. Am. J. Dis. Child. 117:142 (1969).

    PubMed  CAS  Google Scholar 

  37. A.S. Goldman, L.W. Thorpe, R.M. Goldblum, and L.A. Hanson, Antiinflammatory properties of human milk. Acta Paediatr. Scand. 75:689–695 (1986).

    Article  PubMed  CAS  Google Scholar 

  38. A.S. Goldman, R.M. Goldblum, and L.A. Hanson, Anti-inflammatory systems in human milk, in: The Antioxidant Nutrition and Immune Functions Symposium of the Agricultural and Food Chemistry, (Plenum Press, New York and London; 1989) pp. 69–76.

    Google Scholar 

  39. L.W. Thorpe, H.E. Rudloff, L.C. Powell, and A.S. Goldman, Decreased response of human milk leukocytes to chemoattractant peptides. Pediatr. Res. 20:373–377 (1986).

    Article  PubMed  CAS  Google Scholar 

  40. F. Ozkaragoz, H.E. Rudloff, S. Rajaraman, A.A. Mushtaha, F.C. Schmalstieg, and A.S. Goldman, The motility of human milk macrophages in collagen gels. Pediatr. Res. 23:449–452 (1988).

    PubMed  CAS  Google Scholar 

  41. S.E. Keeney, F.C. Schmalstieg, K.H. Palkowetz, H.E. Rudloff, L.E. Binh-Minh, and A.S. Goldman, Activated neutrophils and neutrophil activators in human milk. Increased expression of CD1 lb and decreased expression of L-selectin. J. Leukocyte Biol. 54 (2):97–104 (1993).

    PubMed  CAS  Google Scholar 

  42. A.A. Mushtaha, F.C. Schmaltieg, T.K. Hughes, S. Rajaraman, H.E. Rudloff, and A.S. Goldman, Chemokinetic agents for monocytes in human milk: Possible role of tumor necrosis factor-a. Pediatr. Res. 25:629–633 (1989).

    Article  PubMed  CAS  Google Scholar 

  43. H.E. Rudloff, F.C. Schmalstieg, Jr., A.A. Mushtaha, K.H. Palkowetz, S.K. Liu, and A.S. Goldman, Tumor necrosis factor-a in human milk. Pediatr. Res. 31:29–33 (1992).

    Article  PubMed  CAS  Google Scholar 

  44. D.P. Wirt, L.T. Adkins, K.H. Palkowetz, F.C. Schmalstieg, and A.S. Goldman, Activated-memory T lymphocytes in human milk. Cytometry 13:282–290 (1992).

    Article  PubMed  CAS  Google Scholar 

  45. H.E. Rudloff, F.C. Schmalstieg, Jr., K.H. Palkowetz, and A.S. Goldman, Interleukin-6 in human milk. J. Reprod. Immunol. 23:13–20 (1993).

    Article  PubMed  CAS  Google Scholar 

  46. K.H. Palkowetz, C.L. Royer, R. Garofalo, H.E. Rudloff, F.C. Schmalstieg, Jr., and A.S. Goldman, Production of interleukin-6 and interleukin-8 by human mammary gland epithelial cells. J. Reprod. Immunol. 26:57–64 (1994).

    Article  PubMed  CAS  Google Scholar 

  47. E.S. Buescher and I. Malinowska, Soluble receptors and cytokine antagonists in human milk. Pediatr. Res. 40:839–844 (1996).

    Article  PubMed  CAS  Google Scholar 

  48. A.S. Goldman, S. Chheda, K.H. Palkowetz, H.E. Rudloff, R. Garofalo, and F.C. Schmalstieg, Cytokines in human milk: Their properties and potential effects upon the mammary gland and the recipient infant, in: Journal of Mammary Gland Biology and Neoplasia,Third Edition, edited by M.C. Neville, D. Medina, (Plenum Publishing Corporation, New York, 1996) 1:251–258.

    Google Scholar 

  49. A.S. Goldman, R. Garofalo, and S. Chheda, Spectrum of immunomodulating agents in human milk. Int. J. Pediatr. Hematol/Oncol. 4: 491–497 (1997).

    Google Scholar 

  50. R. Garofalo, S. Chheda, F. Mei, K.H. Palkowetz, H.E. Rudloff, F.C. Schmalstieg, and A.S. Goldman, Interleukin-10 in human milk. Pediatr. Res. 37:444–449 (1995).

    Article  PubMed  CAS  Google Scholar 

  51. S. Chheda, K.H. Palkowetz, R. Garofalo, D.K. Rassin, and A.S. Goldman, Decreased interleukin-10 production by neonatal monocytes and T cells: Relationship to decreased production and expression of tumour necrosis factor-α and its receptors. Pediatr. Res. 40:475–483 (1996).

    Article  PubMed  CAS  Google Scholar 

  52. A.S. Goldman, S. Chheda, and R. Garofalo, Evolution of immunological functions of the mammary gland and the postnatal development of immunity. Pediatr. Res. 43:155–162 (1998).

    Article  PubMed  CAS  Google Scholar 

  53. A.S. Goldman, Modulation of the gastrointestinal tract of infants by human milk. Interfaces and interactions. An evolutionary perspective. J. Nutrition 130(2S Suppl):426S–431S (2000).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer Science+Business Media New York

About this chapter

Cite this chapter

Goldman, A.S. (2002). Macy-György Award Address — Year 2000 a Half-Century Inquiry into the Immunobiology of Human Milk. In: Davis, M.K., Isaacs, C.E., Hanson, L.Å., Wright, A.L. (eds) Integrating Population Outcomes, Biological Mechanisms and Research Methods in the Study of Human Milk and Lactation. Advances in Experimental Medicine and Biology, vol 503. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0559-4_3

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-0559-4_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5132-0

  • Online ISBN: 978-1-4615-0559-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics