Abstract
Colorectal cancer is one of the most common malignancies encountered in the Western World and in-spite of the development of treatment strategies involving adjuvant chemotherapy, hepatic resection, hepatic cryotherapy and Selective Internal Radiation Therapy it continues to claim the lives of approximately 50% of those who develop the disease. While a great deal of effort has gone into the search for effective chemotherapeutic agents, to date no major advance in this area has been forthcoming. In parallel with this effort has been exploration for an effective immunotherapeutic strategy. There is good reason to believe this latter approach may deliver important advances in treatment over the next few years.
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References
Pardoll, D.M., 1998, Cancer vaccines. Nat. Med. 4:525–531.
Ockert, D., Schmitz, M., Hampl, M., Rieber, EP., 1999, Advances in cancer immunotherapy. lmmunol. Today 20:63–65.
Nestle, F.O., Burg, G., Dummer, R., 1999, New perspectives on immunobiology and immunotherapy of melanoma. lmmunol. Today 20:5–7.
Boon, T., Coulie, P.G., Van den Eynde, B., 1997, Tumor antigens recognized by T cells. lmmunol. Today 18:267–268.
Ropponen, K.M., Eskelinen, M.J., Lipponen, P.K., et al., 1997 Prognostic value of tumour-infiltrating lymphocytes (T1Ls) in colorectal cancer. J. Pathol. 182:318–324.
Ambe, K., Mori, M., Enjoji, M., 1989, S-100 protein-positive dendritic cells in colorectal adenocarcinomas. Distribution and relation to the clinical prognosis. Cancer 63:496–503.
Todryk, S.M., Chong, H., Vile, R.G., et al., 1998 Can immunotherapy by gene transfer tip the balance against colorectal cancer? Gut 43:445–449.
. Avery, A., Paraskeva, C., Hall, P., et al., 1993, TGF-ß expression in the human colon: differential immunostaining along crypt epithelium. Br. J. Cancer 68:137–139.
Tsushima, H., Kawata, S., Tamura, S., et al., 1996, High levels of transforming growth factor beta 1 in patients with colorectal cancer: association with disease progression. Gastroenterology 10:375–382.
Gastl, G.A., Abrams, J.S., Nanus, D.M., et al., 1993, Interleukin-10 production by human carcinoma cell lines and its relationship to interleukin-6 expression. Int. J. Cancer 55:96101.
Gabrilovich, D.I., Chen, H.L., Girgis, K.R., et al., 1996, Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat. Med. 2:1096–1103.
Troy, A., Davidson, P., Atkinson, C., Hart, D., 1998, Phenotypic characterisation of the dendritic cell infiltrate in prostate cancer. J. Urol. 160:214–219.
Chaux, P., Moutet, M., Faivre, J., et al., 1996, Inflammatory cells infiltrating human colorectal carcinoma express HLA class II but not B7–1 and B7–2 costimulatory molecules of the T-cell activation. Lab. Invest. 74:975–983.
Saito, T., Dworacki, G., Gooding, W., et al., 2000, Spontaneous apoptosis of CD8+ T lymphocytes in peripheral blood of patients with advanced melanoma. Clin. Can. Res. 6:1351–1364.
Steinman, R.M., Witmer, M.D., 1978, Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice. Proc. Natl. Acad. Sci. USA 75:5132–5136.
Inaba, K., Granelli-Piperno, A., Steinman, R.M., 1983, Dendritic cells induce T Lymphocytes to release B cell-stimulating factors by an interleukin 2-dependent mechanism. J. Exp. Med. 158:2040–2057.
Inaba, K., Steinman, R.M., Van Voorhis, W.C., Muramatsu, S., 1983, Dendritic cells are critical Accessory cells for thymus-dependent antibody responses in mouse and in man. Proc. Natl. Acad. Sci. USA 80:6041–6045.
Feamley, D.B., Whyte, L.F., Camoutsos S.A, et al., 1999, Monitoring human blood dendritic cell numbers in normal individuals and in stem cell transplantation. Blood 93:728–736.
Chen, W., Rains, N., Young, D., Stubbs, R.S., 2000, Dendritic cell-based cancer immunotherapy: Potential for treatment of colorectal cancer? Journal of Gastroenterology and Hepatology 15:698–705.
Morse, M.A., Deng, Y., Coleman, D., et al., 1999, A phase I study of active immunotherapy with carcinoembryonic antigen peptide (CAP-1)-pulsed, autologous human cultured dendritic cells in patients with metastatic malignancies expressing carcinoembryonic antigen. Clin. Cancer Res. 5:1331–1338.
Nair, S.K., Hull, S., Coleman, D., et al., 1999, Induction of carcinoembryonic antigen (CEA)-specific cytotoxic T-lymphocyte responses in vitro using autologous dendritic cells loaded with CEA peptide or CEA RNA in patients with metastatic malignancies expressing CEA. Int. J. Cancer 82:121–124.
Nair, S.K., Boczkowski, D., Morse, M., et al., 1998, Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA. Nat. Biotechnol. 16:364–369.
Gilboa, E., Nair, S.K., Lyerly, H.K., 1998, Immunotherapy of cancer with dendritic-cellbased vaccines. Cancer Immunol. Immunother. 46:82–87.
Ashley, D.M., Faiola, B., Nair, S., et al., 1997, Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors. J. Exp. Med. 186:1177–1182.
Nair, S., Boczkowski, D., Snyder, D., Gilboa, E., 1997, Antigen presenting cells pulsed with unfractionated tumor-derived peptides are potent tumor vaccines. Eur. J. Immunol. 27:589–597.
Nair, S., Snyder, D., Rouse, B.T., Gilboa, E., 1997, Regression of tumors in mice vaccinated with professional antigen-presenting cells pulsed with tumor extracts. Int. J. Cancer 70:706–715.
Fields, R.C., Shimizu, K., Mulo, J.J., 1998, Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune responses in vitro and in vivo. Proc. Natl. Acad. Sci. 95:9482–9487.
Boczkowski, D., Nair, S.K., Snyder, D., Gilboa, E., 1996, Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. J. Exp. Med. 184:465–472.
Zitvogel, L., Mayordomo, J.I., Tjandrawan, T., et al., 1996, Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines. J. Exp. Med. 183:87–97.
Hsu, F.J., Benike, C., Fagoni, F., et al., 1996, Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nat. Med. 2:52–58.
Hsu, F.J., Caspar, C.B., Czerwinski, D., et al., 1997, Tumor-specific idiotype vaccines in the treatment of patients with B-cell lymphoma - long term results of a clinical trial. Blood 89:3129–3135.
Nestle, F.O., Alijagic, S., Gilliet, M., et al., 1998, Vaccination of melanoma patients with peptide-or tumor lysate-pulsed dendritic cells. Nat. Med. 4:328–332.
Murphy, G., Tjoa, B., Ragde, H., et al., 1996, Phase I clinical trial: T-cell therapy for prostate cancer using autologous dendritic cells pulsed with HLA-A0201-specific peptides from prostate-specific membrane antigen. Prostate 29:371–380.
Murphy, G.P., Tjoa, B.A., Simmons, S.J., et al., 1999, Phase II prostate cancer vaccine trial: report of a study involving 37 patients with disease recurrence following primary treatment. Prostate 39:54–59.
Holtl, L., Rieser, C., Papesh, C., et al., 1999, Cellular and humoral immune responses in patients with metastatic renal cell carcinoma after vaccination with antigen pulsed dendritic cells. J. Urol. 161:777–782.
Rains, N., Cannan, R., Chen, W., Stubbs, R.S., 2000, Development of a dendritic cell (DC) based vaccine for patients with advanced colorectal cancer: Hepatogastroenterology (in press).
Young, J.W., Szabolcs, P., Moore, M.A.S., 1995, Identification of dendritic cell colony-forming units among normal CD4+ bone marrow progenitors that are expanded by c-kitligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and tumor necrosis factor alpha. J. Exp. Med. 182:1111–1119.
Flores-Romo, L., Bjorck, P., Duvert, V., et al., 1997, CD40 ligation on human CD34+ hematopoietic progenitors induces their proliferation and differentiation into functional dendritic cells. J. Exp. Med. 185:341–349.
Caux, C., Dezutter-Dambuyant, C., Schmitt, D., Banchereau, J., 1992, GM-CSF and TNFa cooperate in the generation of dendritic Langerhans cells. Nature 360:258–261.
Caux, C., Massacrier, C., Vanbervliet, B., et al., 1994, Activation of human dendritic cells through CD40 cross-linking. J. Exp. Med. 180:1263–1272.
Maraskovsky, E., Brasel, K., Teepe, M., et al., 1996, Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 and ligand-treated mice: multiple dendritic cell subpopulations identified. J. Exp. Med. 184:1953–1962.
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Stubbs, R.S., Rains-Wilson, N., Cannan, R.J., Chen, W. (2002). Development of a Dendritic Cell (DC) Vaccine for Advanced Colorectal Cancer. In: Habib, N.A. (eds) Multi-Treatment Modalities of Liver Tumours. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0547-1_23
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DOI: https://doi.org/10.1007/978-1-4615-0547-1_23
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