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Type 2 Diabetes in Children and Adolescents

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Pediatric Diabetes

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Abstract

Within the past decade there has been a sharp increase in the frequency of type 2 diabetes in adolescents and children1-12. Although this increase has been associated with a rise in the frequency of obesity in the pediatric population, the etiology of type 2 diabetes in the pediatric subjects remains unclear. To better understand the similarities and the differences between pediatric and adult type 2 diabetes and the potential risks type 2 diabetes poses to our youth and future generations, this chapter will compare and contrast the pathophysiology and treatment of both adult and pediatric type 2 diabetes.

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References

  1. Pinhas-Hamiel, O., et al., Increased incidence of non-insulin-dependent diabetes mellitus among adolescents [see comments]. J Pediatr, 1996. 128(5 Pt 1): p. 60845.

    PubMed  Google Scholar 

  2. Glaser, N.S. and K.L. Jones, Non-insulin dependent diabetes mellitus in Mexican-American children. West J Med, 1998. 168(1): p. 11–6.

    PubMed  Google Scholar 

  3. Scott, C.R., et al., Characteristics of youth-onset noninsulin-dependent diabetes mellitus and insulin-dependent diabetes mellitus at diagnosis. Pediatrics, 1997. 100(1): p. 84–91.

    Article  PubMed  CAS  Google Scholar 

  4. Harris, S.B., B.A. Perkins, and E. Whalen-Brough, Non-insulin-dependent diabetes mellitus among First Nations children. New entity among First Nations people of north western Ontario. Can Fam Physician, 1996. 42: p. 869–76.

    PubMed  CAS  Google Scholar 

  5. Fagot-Campagna, A., Knowler, W.C., Pettitt, DJ., Type 2 Diabetes in Pima Indian children: Cardiovascular risk factors at diagnosis and 10 years later. Diabetes, 1998. 47: p. A155.

    Google Scholar 

  6. Fagot-Campagna, A., N.R. Burrows, and D.F. Williamson, The public health epidemiology of type 2 diabetes in children and adolescents: a case study of American Indian adolescents in the Southwestern United States. Clin Chim Acta, 1999. 286(1-2): p. 81–95.

    Article  PubMed  CAS  Google Scholar 

  7. Dabelea, D., et al, Increasing prevalence of Type II diabetes in American Indian children. Diabetologia, 1998. 41(8): p. 904–10.

    Article  PubMed  CAS  Google Scholar 

  8. Hale, D.E., Danney, M.M., Non-insulin dependent diabetes in Hispanic youth (Type 2Y). Diabetes, 1998. 47(Suppl 1): p. A82.

    Article  Google Scholar 

  9. Libman, I.M., et al, Was there an epidemic of diabetes in nonwhite adolescents in Allegheny County, Pennsylvania? Diabetes Care, 1998. 21(8): p. 1278–81.

    Article  PubMed  CAS  Google Scholar 

  10. Pihoker, C, et al, Non-insulin dependent diabetes mellitus in African-American youths of Arkansas. Clin Pediatr (Phila), 1998. 37(2): p. 97–102.

    Article  CAS  Google Scholar 

  11. Fagot-Campagna, A., et al., Type 2 diabetes among North American children and adolescents: an epidemiologic review and a public health perspective. J Pediatr, 2000. 136(5): p. 664–72.

    Article  PubMed  CAS  Google Scholar 

  12. Savage, P.J., et al., High prevalence of diabetes in young Pima Indians: evidence of phenotypic variation in a genetically isolated population. Diabetes, 1979. 28(10): p. 937–42.

    Article  PubMed  CAS  Google Scholar 

  13. Olefsky, J.M., Diabetes mellitus (type II): etiology and pathogenesis, in Endocrinology, LJ. DeGroot, Editor. 1995, W. B. Saunders Company: Philadelphia, p. 1436–63.

    Google Scholar 

  14. Harris, M.L, et al, Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988–1994 [seecomments]. Diabetes Care, 1998. 21(4): p. 518–24.

    Article  PubMed  CAS  Google Scholar 

  15. Narayan, K.M.V., et al., Diabetes - a common, growing, serious, costly, and potentially preventable public health problem. Diabetes Research and clinical Practice, 2000. 50(Suppl. 2): p. S77–S84.

    Article  PubMed  Google Scholar 

  16. Javitt, J.C and Y.-P. Chiang, Economic impact of diabetes, in Diabetes in America, N.Lo. Health, Editor. 1995, National Institutes of Health: Washington D.C. p. 601–11.

    Google Scholar 

  17. Thorburn, A.W., et al., Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non-insulin dependent diabetes mellitus. J Clin Invest, 1991. 87(2): p. 489–95.

    Article  PubMed  CAS  Google Scholar 

  18. Cowie, C.C. and M.L Harris, Physical and metabolic characteristics of persons with diabetes, in Diabetes in America, N.I.o. Health, Editor. 1995, National Institutes of Health: Washington D.C. p. 117–64.

    Google Scholar 

  19. Harris, M.L, et al, Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20-74 yr. Diabetes, 1987. 36(4): p. 523–34.

    Article  PubMed  CAS  Google Scholar 

  20. Haffner, S.M., Epidemiology of type 2 diabetes: risk factors. Diabetes Care, 1998. 21 Suppl 3: p. C3-6.

    Article  PubMed  Google Scholar 

  21. Harris, M.L, Undiagnosed NDDDM: clinical and public health issues. Diabetes Care, 1993. 16(4): p. 642–52.

    PubMed  CAS  Google Scholar 

  22. Harris, M.L, et al., Onset of NIDDM occurs at least 4-7 yr before clinical diagnosis. Diabetes Care, 1992. 15(7): p. 815–9.

    Article  PubMed  CAS  Google Scholar 

  23. Rewers, M. and R.F. Hamman, Risk factors for non-insulin-dependent diabetes, in Diabetes in America, N.I.o. Health, Editor. 1995, National Institutes of Health: Washington D.C. p. 179–20.

    Google Scholar 

  24. Newman, B. et al., Concordance for type 2 (non-insulin-dependent) diabetes mellitus in male twins. Diabetologia, 1987. 30(10): p. 763–8.

    Article  PubMed  CAS  Google Scholar 

  25. Kaprio, J., et al., Concordance for type 1 (insulin dependent) and type 2 (non-insulin- dependent) diabetes mellitus in a population-based cohort of twins in Finland [see comments]. Diabetologia, 1992. 35(11): p. 1060–7.

    Article  PubMed  CAS  Google Scholar 

  26. Bennett, P.H., Epidemiology of non-insulin-dependent diabetes, in Diabetes mellitus: A fundamental and clinical text, D. LeRoith, S.I. Taylor, and J.M. Olefsky, Editors. 1996, Lippincott-Raven: Philadelphia, p. 455–459.

    Google Scholar 

  27. Ravussin, K, et al., Effects of a traditional lifestyle on obesity in Pima Indians. Diabetes Care, 1994. 17(9): p. 1067–74.

    Article  PubMed  CAS  Google Scholar 

  28. Kawate, R., et al., Diabetes mellitus and its vascular complications in Japanese migrants on the Island of Hawaii. Diabetes Care, 1979. 2(2): p. 161–70.

    Article  PubMed  CAS  Google Scholar 

  29. Helmrich, S.P., et al., Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus [see comments]. N Engl J Med, 1991. 325(3): p. 147–52.

    Article  PubMed  CAS  Google Scholar 

  30. Manson, J.E., et al., A prospective study of exercise and incidence of diabetes among US male physicians. Jama, 1992. 268(1): p. 63–7.

    Article  PubMed  CAS  Google Scholar 

  31. Manson, J.E., et al., Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet, 1991. 338(8770): p. 774–8.

    Article  PubMed  CAS  Google Scholar 

  32. Lundgren, H., et al., Fasting serum insulin concentration and early insulin response as risk determinants for developing diabetes. Diabet Med, 1990. 7(5): p. 407–13.

    Article  PubMed  CAS  Google Scholar 

  33. Bennett, P.H., W.C. Knowler, and H.R. Baird, Diet and development of non-insulin-dependent diabetes mellitus: An epidemiological perspective, in Diet, diabetes, and atherosclerosis, P.G. Micossi, A.L. Catapano, and R. Paoletti, Editors. 1984, Raven Press: New York. p. 109.

    Google Scholar 

  34. Bogardus, C., Metabolic abnormalities in the development of non-insulin-dependent diabetes mellitus, in Diabetes mellitus: A fundamental and clinical text, D. LeRoith, S.l. Taylor, and J.M. Olefsky, Editors. 1996, Lippincott-Raven: Philadelphia, p. 459–467.

    Google Scholar 

  35. Caro, J.F., et al., Cellular alterations in liver, skeletal muscle, and adipose tissue responsible for insulin resistance in obesity and type II diabetes. Diabetes Metab Rev, 1989. 5(8): p. 665–89.

    Article  PubMed  CAS  Google Scholar 

  36. Olefsky, J.M., et al., Cellular mechanisms of insulin resistance in non-insulin-dependent (type II) diabetes. Am J Med, 1988. 85(5A): p. 86–105.

    Article  PubMed  CAS  Google Scholar 

  37. Arner, P., et al., Defective insulin receptor tyrosine kinase in human skeletal muscle in obesity and type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia, 1987. 30(6): p. 437–40.

    Article  PubMed  CAS  Google Scholar 

  38. Obermaier-Kusser, B., et al, A defective intramolecular autoactivation cascade may cause the reduced kinase activity of the skeletal muscle insulin receptor from patients with non-insulin-dependent diabetes mellitus. J Biol Chem, 1989. 264(16): p. 9497–504.

    PubMed  CAS  Google Scholar 

  39. Damsbo, P., et al, Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia, 1991. 34(4): p. 239–45.

    Article  PubMed  CAS  Google Scholar 

  40. Nyomba, B.L., et al., Insulin-sensitive tyrosine kinase: relationship with in vivo insulin action in humans. Am J Physiol, 1990. 258(6 Pt 1): p. E964–74.

    PubMed  CAS  Google Scholar 

  41. Shulman, G.I., et al., Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy [see comments]. N Engl J Med, 1990. 322(4): p. 223–8.

    Article  PubMed  CAS  Google Scholar 

  42. Kelley, D.E., M. Mokan, and LJ. Mandarine, Intracellular defects in glucose metabolism in obese patients with NIDDM. Diabetes, 1992. 41(6): p. 698–706.

    Article  PubMed  CAS  Google Scholar 

  43. Matthaei, S., et al., Pathophysiology and pharmacological treatment of insulin resistance. Endocr Rev, 2000. 21(6): p. 585–618.

    Article  PubMed  CAS  Google Scholar 

  44. Saad, M.F., et al., A two-step model for development of non-insulin-dependent diabetes. Am J Med, 1991. 90(2): p. 229–35.

    Article  PubMed  CAS  Google Scholar 

  45. Gepts, W. and P.M. Lecompte, The pancreatic islets in diabetes. Am J Med, 1981. 70(1): p. 105–15.

    Article  PubMed  CAS  Google Scholar 

  46. Saito, K., N. Yaginuma, and T. Takahashi, Differential volumetry of A, B and D cells in the pancreatic islets of diabetic and nondiabetic subjects. Tohoku J Exp Med, 1979. 129(3): p. 273–83.

    Article  PubMed  CAS  Google Scholar 

  47. Ward, W.K., et al., Pathophysiology of insulin secretion in non-insulin-dependent diabetes mellitus. Diabetes Care, 1984. 7(5): p. 491–502.

    Article  PubMed  CAS  Google Scholar 

  48. Everhart, J.E., et al., Duration of obesity increases the incidence of NIDDM. Diabetes, 1992. 41(2): p. 235–40.

    Article  PubMed  CAS  Google Scholar 

  49. Lillioja, S., et al., Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N Engl J Med, 1993. 329(27): p. 1988–92.

    Article  PubMed  CAS  Google Scholar 

  50. Saad, M.F., et al., The natural history of impaired glucose tolerance in the Pima Indians. N Engl J Med, 1988. 319(23): p. 1500–6.

    Article  PubMed  CAS  Google Scholar 

  51. Charles, M.A., et al., Risk factors for NIDDM in white population. Paris prospective study. Diabetes, 1991. 40(7): p. 796–9.

    Article  PubMed  CAS  Google Scholar 

  52. Haffner, S.M., et al., Incidence of type II diabetes in Mexican Americans predicted by fasting insulin and glucose levels, obesity, and body-fat distribution. Diabetes, 1990. 39(3): p. 283–8.

    Article  PubMed  CAS  Google Scholar 

  53. Sicree, R.A., et al., Plasma insulin response among Nauruans. Prediction of deterioration in glucose tolerance over 6 yr. Diabetes, 1987. 36(2): p. 179–86.

    Article  PubMed  CAS  Google Scholar 

  54. Kadowaki, T., et al., Risk factors for worsening to diabetes in subjects with impaired glucose tolerance. Diabetologia, 1984. 26(1): p. 44–9.

    Article  PubMed  CAS  Google Scholar 

  55. Modan, M., et al, Effect of past and concurrent body mass index on prevalence of glucose intolerance and type 2 (non-insulin-dependent) diabetes and on insulin response. The Israel study of glucose intolerance, obesity and hypertension. Diabetologia, 1986. 29(2): p. 82–9.

    Article  PubMed  CAS  Google Scholar 

  56. Haffner, S.M., H. Miettinen, and M.P. Stern, Are risk factors for conversion to NIDDM similar in high and low risk populations? Diabetologia, 1997. 40(1): p. 62–6.

    Article  PubMed  CAS  Google Scholar 

  57. Haffner, S.M., et al., Increased insulin resistance and insulin secretion in nondiabetic African-Americans and Hispanics compared with non-Hispanic whites. The Insulin Resistance Atherosclerosis Study. Diabetes, 1996. 45(6): p. 742–8.

    Article  PubMed  CAS  Google Scholar 

  58. Banerji, M.A., et al., Does intra-abdominal adipose tissue in black men determine whether NEDDM is insulin-resistant or insulin-sensitive? Diabetes, 1995. 44(2): p. 141–6.

    Article  PubMed  CAS  Google Scholar 

  59. Umpierrez, G.E., et al., Diabetic ketoacidosis in obese African-Americans. Diabetes, 1995. 44(7): p. 790–5.

    Article  PubMed  CAS  Google Scholar 

  60. Pinhas-Hamiel, O., L.M. Dolan, and P.S. Zeitler, Diabetic ketoacidosis among obese African-American adolescents with NIDDM. Diabetes Care, 1997. 20(4): p. 484–6.

    Article  PubMed  CAS  Google Scholar 

  61. Dean, H. and M.E. Moffatt, Prevalence of diabetes mellitus among Indian children in Manitoba. Arctic Med Res, 1988. 47(Suppl 1): p. 532–4.

    PubMed  Google Scholar 

  62. Owada, M., et al., Descriptive epidemiology of non-insulin dependent diabetes mellitus detected by urine glucose screening in school children in Japan. Acta Paediatr Jpn, 1990. 32(6): p. 716–24.

    Article  PubMed  CAS  Google Scholar 

  63. Diabetes Control and Complications Trial (DCCT): results of feasibility study. The DCCT Research Group. Diabetes Care, 1987. 10(1): p. 1–19.

    Article  Google Scholar 

  64. Egli, C.A., Increase of early-onset Type 2 Diabetes observed in Asian-Americans as well as other minority youth. Diabetes, 1999. 48(Supph): p. A390.

    Google Scholar 

  65. Rodriguez, B.L., Personal communication. 2001.

    Google Scholar 

  66. Pihoker, C., Personal communication. 2001.

    Google Scholar 

  67. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care, 2001. 24(Supph 1): p. S5–S20.

    Google Scholar 

  68. Verge, C.F., et al., Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop. Diabetes, 1998. 47(12): p. 1857–66.

    Article  PubMed  CAS  Google Scholar 

  69. Turner, R., et al., UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK Prospective Diabetes Study Group. Lancet, 1997. 350(9087): p. 1288–93.

    Article  PubMed  CAS  Google Scholar 

  70. Mueller, P., Personal communication. 2001.

    Google Scholar 

  71. Savola, K., et al., Autoantibodies associated with Type I diabetes mellitus persist after diagnosis in children. Diabetologia, 1998. 41(11): p. 1293–7.

    Article  PubMed  CAS  Google Scholar 

  72. Kolb, H., et al., Prospective analysis of islet cell antibodies in children with type 1 (insulin-dependent) diabetes. Diabetologia, 1988. 31(4): p. 189–94.

    Article  PubMed  CAS  Google Scholar 

  73. Winter, W.E., M. Nakamura, and D.V. House, Monogenic diabetes mellitus in youth. The MODY syndromes. Endocrinol Metab Clin North Am, 1999. 28(4): p. 765–85.

    Article  PubMed  CAS  Google Scholar 

  74. Winter, W.E. and J.H. Silverstein, Molecular and genetic bases for maturity onset diabetes of youth. Curr Opin Pediatr, 2000. 12(4): p. 388–93.

    Article  PubMed  CAS  Google Scholar 

  75. Winter, W.E., et al., Maturity-onset diabetes of youth in black Americans. N Engl J Med, 1987. 316(6): p. 285–91.

    Article  PubMed  CAS  Google Scholar 

  76. Savage, P.J., et al., C-Peptide and insulin secretion in Pima Indians and Caucasians: constant fractional hepatic extraction over a wide range of insulin concentrations and in obesity. J Clin Endocrinol Metab, 1979. 48(4): p. 594–8.

    Article  PubMed  CAS  Google Scholar 

  77. Lev-Ran, A. and D.L. Hwang, C-peptide in NIDDM. Follow-up for 4-6 yr. Diabetes Care, 1993. 16(1): p. 76–81.

    Article  PubMed  CAS  Google Scholar 

  78. Heding, L.G. and S.M. Rasmussen, Human C-peptide in normal and diabetic subjects. Diabetologia, 1975. 11(3): p. 201–6.

    Article  PubMed  CAS  Google Scholar 

  79. Levy, J., et al., Beta-cell deterioration determines the onset and rate of progression of secondary dietary failure in type 2 diabetes mellitus: the 10-year follow-up of the Belfast Diet Study. Diabet Med, 1998. 15(4): p. 290–6.

    Article  PubMed  CAS  Google Scholar 

  80. Turner, R.C., et al., Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. Jama, 1999. 281(21): p. 2005–12.

    Article  PubMed  CAS  Google Scholar 

  81. Jenson, H.B., et al., Treatment of multiple brain abscesses caused by Bacillus cereus. Pediatr Infect Dis J, 1989. 8(11): p. 795–8.

    Article  PubMed  CAS  Google Scholar 

  82. Jiang, X., et al., Racial (black-white) differences in insulin secretion and clearance in adolescents: the Bogalusa heart study. Pediatrics, 1996. 97(3): p. 357–60.

    PubMed  CAS  Google Scholar 

  83. Cowie, C.C., M.I. Harris, and M.S. Eberhardt, Frequency and determinants of screening for diabetes in the U.S. Diabetes Care, 1994. 17(10): p. 1158–63.

    Article  PubMed  CAS  Google Scholar 

  84. Young, L.A., et al., Lipid abnormalities in adolescents with type 2 diabetes (DM). Diabetes, 2000. 49(SuppL): p. A352.

    Google Scholar 

  85. Young, L.A., et al., Prevalence of blood pressure (BP) elevation at diagnosis in adolescents with type 2 diabetes (DM). Diabetes, 1999. 48(Suppl.): p. A368.

    Article  Google Scholar 

  86. Kastrup, E.K., ed. Drug Facts and Comparisons. 2001, Wolters Kluwer Company: St. Louis. 291–312.

    Google Scholar 

  87. Mahler, RJ. and M.L. Adler, Clinical review 102: Type 2 diabetes mellitus: update on diagnosis, pathophysiology, and treatment. J Clin Endocrinol Metab, 1999. 84(4): p. 1165–71.

    Article  PubMed  CAS  Google Scholar 

  88. Preconception care of women with diabetes. Diabetes Care, 2001.24(Suppl. 1): p. S66–S68.

    Google Scholar 

  89. Jones, K., et al., Metformin improves glycemic control in children with Type 2 Diabetes. Diabetes, 2000. 49(SuppL): P A75.

    Google Scholar 

  90. Update: prevalence of overweight among children, adolescents, and adults-United States, 19884994. MMWR Morb Mortal Wkly Rep, 1997. 46(9): p. 198–202.

    Google Scholar 

  91. Must, A., et al., The disease burden associated with overweight and obesity. Jama, 1999. 282(16): p. 1523–9.

    Article  PubMed  CAS  Google Scholar 

  92. Prevalence of overweight among adolescents--United States, 1988-91. MMWR Morb Mortal Wkly Rep, 1994. 43(44): p. 818–21.

    Google Scholar 

  93. Morrison, J.A., et al., Sex and race differences in cardiovascular disease risk factor changes in schoolchildren, 1975-1990: the Princeton School Study. Am J Public Health, 1999. 89(11): p. 1708–14.

    Article  PubMed  CAS  Google Scholar 

  94. Hundred, P., Evidence that young children have joined the race towards obesity. British Medical Journal, 2001. 322: p. 326.

    Article  Google Scholar 

  95. Rosner, B., et al., Percentiles for body mass index in U.S. children 5 to 17 years of age. J Pediatr, 1998. 132(2): p. 211–22.

    Article  PubMed  CAS  Google Scholar 

  96. Matsuzawa, Y., et al., Pathophysiology and pathogenesis of visceral fat obesity. Ann N Y Acad Sci, 1995. 748: p. 399–406.

    Article  PubMed  CAS  Google Scholar 

  97. Goran, M.I. and B.A. Gower, Relation between visceral fat and disease risk in children and adolescents. Am J Clin Nutr, 1999.70(1): p. 149S–56S.

    CAS  Google Scholar 

  98. Kopelman, P.G., Obesity as a medical problem. Nature, 2000. 404(6778): p. 635–43.

    PubMed  CAS  Google Scholar 

  99. Friedman, J.M., Obesity in the new millennium. Nature, 2000. 404(6778): p. 632–4.

    PubMed  CAS  Google Scholar 

  100. Bray, G.A. and L.A. Tartaglia, Medicinal strategies in the treatmentof obesity. Nature, 2000. 404(6778): p. 672–7.

    PubMed  CAS  Google Scholar 

  101. Yokoyama, H., et al., Existence of early-onset NIDDM Japanese demonstrating severe diabetic complications. Diabetes Care, 1997. 20(5): p. 844–7.

    Article  PubMed  CAS  Google Scholar 

  102. Pettitt, D.J., et al., Congenital susceptibility to NIDDM. Role of intrauterine environment. Diabetes, 1988. 37(5): p. 622–8.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Children’s Hospital Medical Center, Cincinnati, OH, USA

    Lawrence M. Dolan MD

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  1. Lawrence M. Dolan MD
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  1. Division of Endocrinology, Metabolism & Diabetes C.S. Mott Children’s Hospital, University of Michigan Health System, Ann Arbor, MI, USA

    Ram K. Menon M.D.

  2. Division of Endocrinology, Metabolism & Diabetes Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Mark A. Sperling M.D.

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Dolan, L.M. (2003). Type 2 Diabetes in Children and Adolescents. In: Menon, R.K., Sperling, M.A. (eds) Pediatric Diabetes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0507-5_3

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