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Ontogeny of the pituitary corticotroph system

  • Maria Nudi
  • Éric Batsché
  • Jacques Drouin
Part of the Endocrine Updates book series (ENDO, volume 21)

Abstract

The pituitary corticotroph cells constitute the central link integrating signals from the brain and periphery to control production of glucocorticoids. Corticotrophs represent one of the two pituitary lineages expressing proopiomelanocortin (POMC). In corticotrophs, POMC is processed into adrenocorticotropin (ACTH) which is the principal regulator of adrenal glucocorticoid synthesis. The other pituitary POMC-expressing lineage is the melanotrophs located in the intermediate lobe of rodents. In these cells, POMC is processed further such that a-melanocyte stimulating hormone (aMSH) is produced instead of ACTH. The single copy POMC gene is expressed in both pituitary lineages but under different developmental and hormonal regulatory pathways. At the cellular level, this regulation is exerted by transcription factors that regulate both POMC transcription and cell differentiation.

Keywords

Leukemia Inhibitory Factor Orphan Nuclear Receptor POMC Gene bHLH Factor Pituitary Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Maria Nudi
    • 1
  • Éric Batsché
    • 1
  • Jacques Drouin
    • 1
  1. 1.Institut de recherches cliniques de Montréal (IRCM)Université de MontréalMontreal

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