Widespread use of increasingly sophisticated gene-targeting technologies has created a growing interest in the physiological genomics of mice. The study of the role of specific genes in organ function has motivated investigators in the field of cardiovascular research to adapt techniques first used in humans and large animals to evaluate cardiac phenotypes in mice. Since its first application in this field in the late 1990s, echocardiography has become the most widely used noninvasive technique for studying cardiac structure and function in genetically manipulated mice. Although not specifically developed for this purpose, technical improvements in ultrasound imaging systems have allowed investigators to extend studies into more and more diverse areas of cardiac physiology. These technical improvements, coupled with increasingly refined time-and dose-dependent organ-specific genetic manipulations have dramatically increased our understanding of both the advantages and limitations inherent in using mouse models to study human cardiac disease.
KeywordsLeft Ventricle Pressure Overload Physiol Heart Circ Transverse Aortic Constriction Left Ventricle Mass
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