Skip to main content
SpringerLink
Log in
Book cover

Pathophysiology of Cardiovascular Disease pp 545–554Cite as

Cellular Cardiomyoplasty: The Role of Bone Marrow Stromal Cells in Myocardial Tissue Regeneration

  • Chapter

  • 299 Accesses

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 10))

Summary

Bone marrow stromal cells (MSCs) are multipotent adult stem-cells capable of regenerating a variety of adult tissues. This review examines the use of MSCs as a source of myocardial tissue regeneration, concentrating on the recent history of experiments examining the pathophysiological role of MSCs following myocardial infarction and their therapeutic use in regenerative cardiology. It provides an up-to-date review of current trials examining the functional impact of MSC implantation into an injured myocardium and discusses the future directions and potential pitfalls of this active area of research.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. American Heart Association. Heart and Stroke Statistical Update. 2000.

    Google Scholar 

  2. Kao RL, Rohwedel J, Magovern GJ. 1989. Satellite cells for myocardial regeneration. Physiologist 32:220.

    Google Scholar 

  3. Chiu RCJ, Zibaitis A, Kao RL. 1995. Cellular cardiomyoplasty: myocardial regeneration with satellite cell implantation. Ann Thor Surg 60:12–18.

    CAS  Google Scholar 

  4. Marelli D, Desrosiers C, El-Alfy M, Kao RL, Chiu RCJ. 1992. Cell transplantation for myocardial repair: an experimental approach. Cell Transplant 1:383–390.

    PubMed  CAS  Google Scholar 

  5. Muller M, Fleishmann B, Selbert S, Ji G, Endl E, Middeler G, Muller O. 2000. Selection of ventricular-like cardiomyocytes from ES cells in vitro. FASEB 14:254–2548.

    Article  Google Scholar 

  6. Li RK, Mickle DA, Weisel RD, Zhang J, Mohabeer MK. 1996. In vivo survival and function of transplanted rat cardiomyocytes. Circ Res 78:283–288.

    Article  PubMed  CAS  Google Scholar 

  7. Maltsev VA, Rohwedel J, Hescheler J, Wobus AM. 1993. Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types. Mech Dev 44:41–50.

    Article  PubMed  CAS  Google Scholar 

  8. Wang JS, Shum-Tim D, Galipeau J, Chedrawy E, Eliopoulos N, Chiu RCJ. 2000. Marrow stromal cells for cellular cardiomyoplasty: feasability and potential clinical advantages. J Thorac Cardiovasc Surg 120:999–1006.

    Article  PubMed  CAS  Google Scholar 

  9. Friedenstein AJ, Gorskoja V, Kulagina NN. 1976. Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp Hematol 4:267–274.

    PubMed  CAS  Google Scholar 

  10. Peterson BE, Bowen WC, Patrene KD, Mars WM, Sullivan AK, Murase N, Boggs SS, Greenberger JS, Goff JP. 1999. Bone marrow as a potential source of hepatic oval cells. Science 284:1168–1170.

    Article  Google Scholar 

  11. Woodbury D, Schwarz EJ, Prockop DJ, Black IB. 2000. Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 61:364–370.

    Article  PubMed  CAS  Google Scholar 

  12. Bittira B, Kuang JQ, Piquer S, Shum-Tim D, Al-Khaldi A, Chiu RCJ. 2002. The Pathophysiological Roles of Bone Marrow Stromal Cells (MSCs) In Myocardial Infarction. Circulation 104(Suppl II):II–523.

    Google Scholar 

  13. Wakitani S, Saito T, Caplan A. 1995. Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve 18:1417–1426.

    Article  PubMed  CAS  Google Scholar 

  14. Makino S, Fukudi K, Miyoshi S, Konishi F, Kodama H, Pan J, Sano M, Takahashi T, Hori S, Abe H, Hata J, Umezawa A, Ogawa S. 1999. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 103:697–705.

    Article  PubMed  CAS  Google Scholar 

  15. Konieczny SF, Emerson CP. 1984. 5-azacytidine induction of stable mesodermal stem cell lineages from 10T1/2 cells: evidence for regulatory genes controlling determination. Cell 38:791–800.

    Article  PubMed  CAS  Google Scholar 

  16. Tomita S, Li RK, Weisel RD. 1999. Autologous transplantation of bone marrow stromal cells improves damaged heart function. Circulation 100(Suppl II):247–256.

    Google Scholar 

  17. Wang JS, Shum-Tim D, Galipeau J, Chedrawy E, Eliopoulos N, Chiu RCJ. 2000. Marrow stromal cells for cellular cardiomyoplasty: feasability and potential clinical advantages. J Thorac Cardiovasc Surg 20:999–1006.

    Article  Google Scholar 

  18. Wang JS, Shum-Tim D, Chedrawy E, Eliopoulos N, Galipeau J, Chiu RCJ. 2000. Marrow stromal cells for cellular cardiomyoplasty: The importance of microenvironment for milieu dependent differentiation. Presented at the annual meeting of the American Heart Association.

    Google Scholar 

  19. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, Pickel J, McKay R, Nadel-Ginard B, Bodine DM, Leri A, Anversa P. 2001. Bone marrow cells regenerate infarcted myocardium. Nature 410:701–705.

    Article  PubMed  CAS  Google Scholar 

  20. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, Pickel J, McKay R, Nadel-Ginard B, Bodine DM, Leri A, Anversa P. 2001. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Nat Acad Sci 98:10344–10349.

    Article  PubMed  CAS  Google Scholar 

  21. Wang JS, Shum-Tim D, Chedrawy E, Chiu RCJ. 2001. The coronary delivery of marrow stromal cells for myocardial regeneration: Pathophysiologic and therapeutic implications. J Thorac Cardiovasc Surg 121:1–7.

    Article  Google Scholar 

  22. Kocher AA, Schuster MD, Szabolcs MJ, Takuma S, Burkhoff D, Wang J, Homma S, Edwards NM, Itescu S. 2001. Neovascularization of ischemic myocardium by human bone marrow derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 7:430–436.

    Article  PubMed  CAS  Google Scholar 

  23. Hakuno D, Fukuda K, Makino S, Konishi F, Tomita Y, Manabe T, Suzuki Y, Umezawa A, Ogawa S. 2002. Bone marrow-derived regenerated cardiomyocytes (CMC cells) express functional adrenergic and muscarinic receptors. Circulation 105:380–386.

    Article  PubMed  CAS  Google Scholar 

  24. Gorman R. 2002. Cellular myoplasty: What are we really trying to achieve? J Thorac Cardiovasc Surg 123:582–583.

    Article  PubMed  Google Scholar 

  25. Brazelton TR, Rossi FM, Keshet GI, Blau HM. 2000. From marrow to brain: expression of neuronal phenotypes in adult mice. Science 290:1779.

    Article  Google Scholar 

  26. Bruder SP, Fink DJ, Caplan AL. 1994. Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem 56:283–294.

    Article  PubMed  CAS  Google Scholar 

  27. Terada N, Hamazaki T, Oka M, Hoki M, Mastalerz DM, Nakano Y, Meyer EM, Morel L, Petersen BE. 2001. Bone marrow cells adopt the phenotvpe of other cells by spontaneous cell fusion. Nature 416:542–545.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Cardiac Surgery, The Montreal General Hospital, MUHC, 1650 Cedar Avenue, Suite C9-169, H3G 1A4, Montreal, Quebec, Canada

    Derek J. MacDonald & M.D., Ph.D. Ray C.-J. Chiu

Authors
  1. Derek J. MacDonald
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M.D., Ph.D. Ray C.-J. Chiu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ray C.-J. Chiu .

Editor information

Editors and Affiliations

  1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla PhD, MD (Hon), DSc (Hon) (Distinguished Professor and Director) (Distinguished Professor and Director)

  2. Philipps University of Marburg, Marburg, Germany

    Heinz Rupp PhD (Professor of Medicine) (Professor of Medicine)

  3. Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Aubie Angel MD (Professor of Internal Medicine) (Professor of Internal Medicine)

  4. Division of Stroke & Vascular Disease St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Grant N. Pierce PhD, FACC (Professor & Director) (Professor & Director)

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

MacDonald, D.J., Chiu, R.CJ. (2004). Cellular Cardiomyoplasty: The Role of Bone Marrow Stromal Cells in Myocardial Tissue Regeneration. In: Dhalla, N.S., Rupp, H., Angel, A., Pierce, G.N. (eds) Pathophysiology of Cardiovascular Disease. Progress in Experimental Cardiology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0453-5_38

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-0453-5_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5084-2

  • Online ISBN: 978-1-4615-0453-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation