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Molecular Genetics of Kidney Cancer

  • Michael Zimmer
  • Othon Iliopoulos
Part of the Cancer Treatment and Research book series (CTAR, volume 116)

Abstract

Tumorigenesis is a multistep process of genetic and epigenetic changes that occur in an orderly fashion The order of these changes may navigate through different steps in cancers arising from different organs/tissues. It is likely though that the final outcome is the sequential deregulation of a few key pathways of normal cell growth, namely: inactivation of tumor suppressor genes; activation of oncogenes; evasion of apoptotic cell program; and ultimately induction of angiogenesis and metastasis.’ Entry points to these genetic alterations were discovered by cloning genes disrupted by tumor-associated chromosomal translocations, harbored in cancer-associated homozygous deletions or underlying familial cancer syndromes.

Keywords

Hypoxia Inducible Factor Tuberous Sclerosis Tuberous Sclerosis Complex Papillary Renal Cell Carcinoma Tuberous Sclerosis Complex Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Michael Zimmer
    • 1
  • Othon Iliopoulos
    • 1
  1. 1.From The Massachusetts General Hospital Cancer Center and MGH Familial Renal Cancer ClinicHarvard Medical SchoolBoston

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