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The Sodium-Hydrogen Exchanger pp 123–136Cite as

pH-Regulatory Mechanisms in the Mammalian Oocyte and Early Embryo

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Abstract

Na+/H+ exchangers and intracellular pH (pHi) regulation assumed a central position in the study of fertilization following the discovery that egg activation in the sea urchin is triggered in part by a substantial pHj increase immediately after fertilization, and that this increase is mediated by the activation of Na+/H+ exchange (1). In mammals, the regulation of pHi has been extensively studied in early embryos, with more recent attention given to the role of pHi-regulatory mechanisms during fertilization and meiosis in the oocyte. This review will focus principally on pHi-regulatory mechanisms in mammalian oocytes and preimplantation embryos during meiosis, fertilization, and embryo development.

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Author information

Authors and Affiliations

  1. Ottawa Health Research Institute and University of Ottawa, Ottawa, Ontario, Canada

    Jay M. Baltz

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  1. Jay M. Baltz
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Editors and Affiliations

  1. University of Western Ontario, London, Ontario, Canada

    Morris Karmazyn

  2. King’s College London, UK

    Metin Avkiran

  3. University of Alberta, Edmonton, Alberta, Canada

    Larry Fliegel

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© 2003 Springer Science+Business Media New York

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Baltz, J.M. (2003). pH-Regulatory Mechanisms in the Mammalian Oocyte and Early Embryo. In: Karmazyn, M., Avkiran, M., Fliegel, L. (eds) The Sodium-Hydrogen Exchanger. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0427-6_8

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  • DOI: https://doi.org/10.1007/978-1-4615-0427-6_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5071-2

  • Online ISBN: 978-1-4615-0427-6

  • eBook Packages: Springer Book Archive

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