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A Role for the Phosphatidylinositol-3-Kinase Pathway in Preconditioning

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Book cover Myocardial Ischemia and Preconditioning

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 6))

Summary

Preconditioning has been shown to reduce cell death, although the mechanism responsible is still unclear. Activation of phosphatidylinositol-3-kinase (PI3K) has been shown to be cardioprotective. This paper will review the data suggesting a role for the PI3K pathways in cardioprotection and preconditioning. The PI3K pathway is activated by preconditioning and inhibition of PI3K blocks the protective effects of preconditioning. Thus, enhanced cell survival via activation of PI3K appears to be important in preconditioning.

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Authors and Affiliations

  1. Laboratory of Signal Transduction, NIEHS Research Triangle Park, 27709, NC, USA

    Elizabeth Murphy & Haiyan Tong

  2. Department of Pathology, Duke University Medical Center Durham, 27710, NC, USA

    Charles Steenbergen

Authors
  1. Elizabeth Murphy
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  2. Haiyan Tong
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  3. Charles Steenbergen
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Corresponding author

Correspondence to Elizabeth Murphy .

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Editors and Affiliations

  1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla PhD, MD (Hon), DSc (Hon) (Distinguished Professor and Director) & Anton Lukas PhD (Associate Professor) (Distinguished Professor and Director) &  (Associate Professor)

  2. Aoto Hospital, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan

    Nobuakira Takeda MD, PhD (Associate Professor) (Associate Professor)

  3. Dept. of Pharmaceutical Sciences & Drug Research, Punjabi University, Patiala, India

    Manjeet Singh PhD (Professor & Head) (Professor & Head)

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Murphy, E., Tong, H., Steenbergen, C. (2003). A Role for the Phosphatidylinositol-3-Kinase Pathway in Preconditioning. In: Dhalla, N.S., Takeda, N., Singh, M., Lukas, A. (eds) Myocardial Ischemia and Preconditioning. Progress in Experimental Cardiology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0355-2_19

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  • DOI: https://doi.org/10.1007/978-1-4615-0355-2_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5036-1

  • Online ISBN: 978-1-4615-0355-2

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