Summary
Granulocyte activation and adhesion molecule expression are causal factors in microcirculatory disorders during myocardial reperfusion. While the dynamics of these processes have been well defined during acute reperfusion, there is very little data regarding long lasting reperfusion. The aim of this study was to investigate leukocyte adhesion molecule expression during myocardial ischemia followed by 4 weeks of reperfusion. The left descending coronary artery (LAD) was occluded in dogs for 1 hour and 3 hours followed by 4 weeks of reperfusion. Sham operated animals served as control. Leukocyte expression of CD11a was measured by flow cytometry in peripheral blood samples. Granulocyte CD11a expression started to increase at the second day of reperfusion with the maximal elevation (p < 0.05) by the third postoperative day in ischemic animals. The similar elevation in sham operated animals normalised within the first postoperative week, however, CD11a expression was elevated in both groups of ischemic animals even after 4 weeks reperfusion. The increased CD11a expression during first postoperative week may reflect the effect of surgical trauma, but the elevated leukocyte function during later reperfusion may indicate the activated state of cells and the prolonged healing of injured myocardium.
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Röth, E., Jancsó, G., Temes, G., Lantos, J. (2003). Long Term Follow-Up of Leukocyte Function during Myocardial Reperfusion Injury. In: Dhalla, N.S., Takeda, N., Singh, M., Lukas, A. (eds) Myocardial Ischemia and Preconditioning. Progress in Experimental Cardiology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0355-2_10
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