Summary
KLF5/BTEB2 is a Krüppel-like zinc-finger type transcription factor of a non-muscle type myosin heavy chain gene SMemb, which is markedly induced in phenotypically modulated smooth muscle (SMC). KLF5/BTEB2 expression in SMC is downregulated with vascular development in vivo but upregulated in neointima that is produced in response to vascular injury. KLF5/BTEB2 activates the promoter of not only SMemb gene, but also of other genes which are actvated in synthetic SMC, including plasminogen activator inhibitor-1 (PAI-1), iNOS, PDGF-A, Egr-1 and VEGF receptors. Mitogenic stimulation activates KLF5/BTEB2 gene expression through MEK1 and Egr-1. KLF5/BTEB2 +/- mice showed a marked reduction in neointimal formation, angiogenesis and cardiac fibrosis induced by various kinds of stress. We suggest that KLF5/BTEB2 is a crucial transcription factor involved in smooth muscle phenotypic modulation as well as mesenchymal cell activation in cardiovascular disease.
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© 2003 Springer Science+Business Media New York
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Nagai, R. et al. (2003). KLF5/BTEB2, a Krüppel-like Transcription Factor, Regulates Smooth Muscle Phenotypic Modulation. In: Dhalla, N.S., Hryshko, L.V., Kardami, E., Singal, P.K. (eds) Signal Transduction and Cardiac Hypertrophy. Progress in Experimental Cardiology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0347-7_30
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DOI: https://doi.org/10.1007/978-1-4615-0347-7_30
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