Summary
An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves the release of angiotensin II (Ang II), the release/increased formation of endothelin (ET), the activation of the Na+/H+ exchanger (NHE), the increase in intracellular Na+ concentration ([Na+]i), and the increase in the Ca2+ transient that underlies the so called slow force response (SFR) to stretch. This autocrine/paracrine mechanism could explain how a change in afterload alters cardiac contractility as was reported by Anrep in 1912.
Established Investigators of Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.
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Cingolani, H.E., Perez, N.G., de Hurtado, M.C.C. (2003). Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart. In: Dhalla, N.S., Hryshko, L.V., Kardami, E., Singal, P.K. (eds) Signal Transduction and Cardiac Hypertrophy. Progress in Experimental Cardiology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0347-7_3
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DOI: https://doi.org/10.1007/978-1-4615-0347-7_3
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