Most neurotransmitter receptors are relatively simple on/off switch mechanisms, turned on by the binding of their neurotransmitter hormone and turned off in its absence. Receptor channels, for example, are open when turned on and closed when turned off, a straightforward and tidy arrangement. The cyclic process of D4 receptor-mediated PLM is, however, definitely different, with features designed to make it responsive to and contingent upon prevailing metabolic conditions. For as much as D4R-mediated PLM is involved in attention and attention-related learning, this implies that these mental capacities will be affected by changes in our metabolism, an example of the “Mind/Body Connection” in action. In this Chapter we’ll examine the molecular basis for this connection, with special attention to changes that occur over the human lifespan.
KeywordsCobalt Cortisol Glycine Anemia Serine
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