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Cytokines and Appetite

  • Wolfgang Langhans
  • Brian J. Hrupka
Part of the Neurobiological Foundation of Aberrant Behaviors book series (NFAB, volume 7)

Abstract

Cytokines are known to orchestrate non-specific and specific immune reactions and are broadly categorized as being pro-inflammatory or antiinflammatory. In addition to their pleiotropic effects in the immune system, cytokines affect other physiologic functions and cause CNS-mediated effects such as fever, sleep, and an activation of the hypothalamic-pituitary-adrenal axis. Moreover, several pro-inflammatory cytokines, such as interleukin-1 (IL-1), IL-2, IL-6, IL-8, tumor necrosis factor-α (TNFα) and interferon-γ (IFNγ) suppress appetite. The cytokine-induced suppression of appetite, i.e. the resulting anorexia and hypermetabolism are major contributors to the cachexia of chronic diseases, and part of the organism’s acute phase response to various immune stimuli. Acute, short-term anorexia during an immune challenge is considered to be beneficial for the host. For example, force-feeding experimentally infected mice to the control levels reduced survival time and increased mortality (1). Sustained cytokine-mediated anorexia, however, which occurs during chronic infections, cancer and other chronic diseases can compromise the host’s ability to fight disease. Cytokines also presumably contribute to the anorexia and cachexia that promote fragility in aging people. Thus, the appetite suppressing effect of cytokines is a practically relevant and scientifically interesting research problem with various facets.

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Copyright information

© Springer Science+Business Media Dordrecht 2003

Authors and Affiliations

  • Wolfgang Langhans
    • 1
  • Brian J. Hrupka
    • 1
  1. 1.Institute of Animal Sciences, Swiss Federal Institute of Technology (ETH)ZurichSwitzerland

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