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The effect of early treatment by cerivastatin on the serum level of C-reactive protein, interleukin-6, and interleukin-8 in the patients with unstable angina and non-Q-wave myocardial infarction

  • Petr Ostadal
  • David Alan
  • Petr Hajek
  • David Horak
  • Jiri Vejvoda
  • Jiri Trefanec
  • Martin Mates
  • Jan Vojacek
Part of the Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease book series (DMCB, volume 41)

Abstract

The aim of our study was to evaluate whether a single dose of cerivastatin at the time of admission of patients with unstable angina pectoris (UAP) or non-Q-wave myocardial infarction (NQMI) can influence the serum level of C-reactive protein (CRP), interleukin-6 (IL-6) and interleukin-8 (IL-8) 24 h later. Forty-four patients with rest chest pain and subendocardial ischemia on ECG were randomized to receive cerivastatin 0.3 mg at the time of admission (group C+) to standard therapy or to remain just on standard therapy (group C—). Blood samples for determination of troponin I (TI), CRP, IL-6 and IL-8 were collected at admission (entry level) and 24 h later (final level). Patients with non-physiological baseline levels of TI, as well as patients with progression to Q wave MI were excluded. All baseline, clinical and demographic data and final values of TI were comparable in the two groups. In patients treated with cerivastatin (group C+ n =13) we observed decrease in the CRP level (-6.73

3.93 mg/L); on the other hand, in group C- (n =17) the CRP level increased (+7.92 ± 2.77 mg/L, p = 0.004). Similar differences were observed also in IL-6: in group C+ the level was significantly reduced as compared with the increase in group C-(-0.76 ± 0.52 vs. 4.58 ± 1.49 ng/L, p = 0.005). The level of IL-8 was not affected. Our results suggest that early treatment with cerivastatin can decrease the serum level of CRP and IL-6 in patients with UAP/NQMI; this might positively influence their prognosis. Nevertheless, further studies are needed to support this hypothesis. (Mol Cell Biochem246:45-50, 2003)

Key words:

cerivastatin inflammation C-reactive protein interleukin unstable angina myocardial infarction 

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Copyright information

© Springer Science+Business Media Dordrecht 2003

Authors and Affiliations

  • Petr Ostadal
    • 1
  • David Alan
    • 1
  • Petr Hajek
    • 1
  • David Horak
    • 1
  • Jiri Vejvoda
    • 1
  • Jiri Trefanec
    • 1
  • Martin Mates
    • 1
  • Jan Vojacek
    • 1
  1. 1.Department of Internal MedicineUniversity Hospital Motol and 2nd Medical Faculty, Charles University, PragueCzech Republic

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