Abstract
The prefrontal cortex (PFCx) can be divided into the lateral, orbital and medial PFCx, which all contribute to attentional and novelty processing and flexible behaviors. The cytoarchitecture of lateral prefrontal cortex (LPFCx) is highly organized, differentiated, distinctly layered, granular isocortex while the orbitofrontal cortex (OFCx) is structurally more heterogeneous, less differentiated, agranular limbic cortex (Barbas, 2000). The LPFCx is interconnected with parietal/occipital visual association areas, posterior parietal heteromodal areas, and inferior temporal visual association areas (Kaufer & Lewis, 1999). Other main circuitries of the LPFCx include reciprocal connections with the cingulate and the orbitofrontal cortex. In contrast, the OFCx has extensive direct and indirect connections with limbic areas such as the amygdala complex, hypothalamus, and the hippocampal formation (Cavada et al., 2000), with additional interactions to the inferior temporal visual association areas and LPFCx (Kaufer & Lewis, 1999). The main connections of the LPFCx to association areas and the OFCx to limbic areas determine the primary behavioral functions of these areas, with the LPFCx well-suited for attentional and executive function and the OFCx for affective and reward-related functions.
Keywords
- Prefrontal Cortex
- Orbitofrontal Cortex
- Clinical Neurophysiology
- International Affective Picture System
- Novelty Detection
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Hartikainen, K.M., Knight, R.T. (2003). Lateral and Orbital Prefrontal Cortex Contributions to Attention. In: Polich, J. (eds) Detection of Change. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0294-4_6
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