Sensitizing Calcium-Induced Calcium Release

Role of cADPR as an Endogenous Modulator


The primary mechanism by which cells effect rapid increases in their intracellular Ca2+ concentration ([Ca2+ ]i) is by the opening (gating) of specific channels which facilitate the passage of Ca2+ across a membrane down the electrochemical gradient generated by various pumps and/or exchangers. Whether at the plasma membrane or on intracellular organelles (e.g. endoplasmic reticulum (ER), mitochondria, Golgi), such channels have to be tightly controlled to prevent deleterious or inappropriate elevations of the [Ca2+ ]i. Therefore, cells have developed a seemingly varied repertoire for their discrete regulation. However, this apparent complexity belies the fact that activation, in essence, encompasses only three modes of operation: (a) ligand-gated ion channels (b) voltage-gated ion channels (c) channels regulated by protein-protein interactions.


Release Channel Ryanodine Receptor Pancreatic Acinar Cell Nicotinic Acid Adenine Dinucleotide Phosphate Ryanodine Binding 
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© Springer Science+Business Media New York 2002

Authors and Affiliations

  1. 1.Department of PharmacologyOxford UniversityOxfordUK

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