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Separate but Interacting Calcium Stores

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Cyclic ADP-Ribose and NAADP

Abstract

Mobilization of intracellular Ca2+ stores is a principal signaling mechanism employed by cells to respond to a wide variety of stimuli, both external and internal. One of the most dramatic examples occurs during fertilization. Immediately after sperm-egg fusion, a highly localized Ca2+ elevation is initiated right at the fusion site. This spark of Ca2+ then grows into a wave propagating across the entire egg. Intriguingly, the initiation of apoptotic cell death also involves Ca2+ mobilization. How cells can differentiate between Ca2+ signals as disparate as those governing life and death is a question of fundamental importance.

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  1. Department of Pharmacology, University of Minnesota, 321 Church St., SE, 4-145 Jackson Hall, Minneapolis, MN, 55455, USA

    Hon Cheung Lee

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Lee, H.C. (2002). Separate but Interacting Calcium Stores. In: Lee, H.C. (eds) Cyclic ADP-Ribose and NAADP. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0269-2_8

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  • DOI: https://doi.org/10.1007/978-1-4615-0269-2_8

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