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ADP-Ribosylation and CD38 Signaling

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Abstract

Mono-ADP-ribosylation is a posttranslational protein modification reaction that was originally discovered as a mechanism by which bacterial toxins interfere with signal transduction in human host cells [1, 2]. Mono-ADP-ribosylation is also used as a mechanism to regulate endogenous metabolism, as clearly demonstrated in photosynthetic bacteria [3]. Mammalian endogenous mono-ADP-ribosylation has also been studied and the responsible enzymes have been purified and defined at the molecular level [4–9].

Keywords

Insulin Secretion Islet Cell CD38 Signaling Nicotinamide Adenine Dinucleotide Endocytic Vesicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  1. 1.Department of BiochemistryChonbuk National University Medical SchoolChonjuKorea
  2. 2.Department of Internal MedicineChonbuk National University Medical SchoolChonjuKorea
  3. 3.Institute for Medical SciencesChonbuk National University Medical SchoolChonjuKorea

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