ADP-Ribosylation and CD38 Signaling
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Mono-ADP-ribosylation is a posttranslational protein modification reaction that was originally discovered as a mechanism by which bacterial toxins interfere with signal transduction in human host cells [1, 2]. Mono-ADP-ribosylation is also used as a mechanism to regulate endogenous metabolism, as clearly demonstrated in photosynthetic bacteria . Mammalian endogenous mono-ADP-ribosylation has also been studied and the responsible enzymes have been purified and defined at the molecular level [4–9].
KeywordsInsulin Secretion Islet Cell CD38 Signaling Nicotinamide Adenine Dinucleotide Endocytic Vesicle
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